葡萄膜炎是主要的致盲性眼病之一，严重影响患者生活质量，被认为与患者免疫失衡密切相关，常规的治疗主要针对炎症控制，但是即便炎症得到很好的控制，患者的视功能依然受损难以恢复。最近我们的前期研究发现，炎症反应早期即可导致光感受器细胞的损伤，但是这种损伤的机制尚且不清，难以针对光感受器细胞的损伤进行干预。SND1蛋白是一种功能蛋白，与细胞周期和细胞应激密切相关，可能参与了炎症的应激反应过程，并且在细胞DNA的损伤和细胞死亡中发挥抑制作用。本研究拟通过构建SND1蛋白干预的光感受器细胞系和SND1基因敲除的自身免疫性葡萄膜炎小鼠模型，观察SND1蛋白对其炎性反应的影响及光感受器细胞损伤的保护作用，探讨SND1蛋白参与光感受器细胞DNA损伤修复的机制，寻求葡萄膜炎中光感受器细胞损伤和保护的可能策略。

Uveitis is one of the major blinding eye disease, seriously affecting the quality of life of patients, it is considered closely related to immune imbalance of patients, it’s conventional therapy is aiming at controlling inflammation, but even if the inflammation is well controlled, the patient's visual function will remain damaged and difficult to restore. Recent preliminary studies have found that early inflammatory response can lead to photoreceptor cell damage, but the mechanism of this injury is not clear yet, it is difficult to intervene against photoreceptor cell injury. SND1 protein is a functional protein which is closely related to the cell cycle and cell stress, it may be involved in the stress response process of inflammation and plays an important role in inhibition of DNA damage and cell death. This study is aiming to observe the effects of SND1 Protein on inflammatory response and the protective effect of photoreceptor cell’s injury, to explore repair mechanisms of cell DNA damage where SND1 photoreceptor proteins involved in and to seek possible strategies of uveitis photoreceptor cell damage and protection by constructing SND1 intervened photoreceptor cell line and SND1 knockout mouse model of autoimmune uveitis.