卵巢癌在女性生殖系统肿瘤中致死率居于首位，其中约75%为高级别浆液性癌，发病机制一直存在争议。近年来输卵管起源假说为卵巢癌的发病机制提供了新的研究视角。我们的前期工作表明：相对于卵巢上皮，卵巢高级别浆液性癌和输卵管上皮具有更高的基因表达谱相似性，支持输卵管起源模型。基于基因谱分析及参考相关文献，我们筛选出上调基因TACSTD2。本项目拟阐明TACSTD2对卵巢高级别浆液性癌发生发展的影响，并揭示其是否通过激活ERK/MAPK通路发挥作用。首先将扩大样本量以验证TACSTD2与卵巢高级别浆液性癌的相关性；然后通过功能研究及动物实验明确其对肿瘤生物学行为的影响；分析TACSTD2与ERK/MAPK通路的作用机制并筛选上下游基因；最后检测其在蜡块标本中的表达，评估其在临床诊断预后方面的应用前景。本研究将从TACSTD2这个新视点为揭示卵巢高级别浆液性癌的发病机制及临床诊断预后提供新的思路。

Ovarian cancer is the most lethal cause of cancer death among women. Recent studies have suggested that fallopian tube is the likely source of ovarian high-grade serous cancer which is considered as the most common histotype of ovarian carcinoma. Until now, there are mainly morphological and evidences, but few genetic findings. Based on our previous study, ILLUMINA Beadarray was used to find the homology in the aspect of gene expression profile between ovarian serous carcinoma and fallopian tube, and select candidate marker TACSTD2. We speculate that TACSTD2 could drive the expression of NF-κB、Cyclin D1 through the activation of ERK/MAPK pathway and then play role in the carcinogenesis and development of high-grade ovarian serous carcinoma. Next step the experiments in vivo and vitro will be performed, to clarify the molecular mechanism of TACSTD2. The expression TACSTD2 in tissue blocks will be tested, to evaluate its prospect in clinic. Our study will supply genetic evidences for tubal origin of high grade ovarian serous carcinoma and potential candidate marker for tumor diagnosis and treatment.