Mucin-1/Wnt/β-catenin通路在高血压肾脏纤维化中的调控作用及机制研究
结题报告
批准号:
81970353
项目类别:
面上项目
资助金额:
55.0 万元
负责人:
黄绮芳
依托单位:
学科分类:
血压调节异常与高血压病
结题年份:
2023
批准年份:
2019
项目状态:
已结题
项目参与者:
黄绮芳
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中文摘要
肾脏是高血压的重要靶器官之一。Mucin-1在肾小管上皮细胞高表达,可能通过某些机制导致上皮-间质转化(EMT),造成肾纤维化。Mucin-1过表达及在Galectin-3等因素作用下,可激活癌细胞内Wnt/β-catenin通路,而该通路激活与EMT效应物表达增加相关。Mucin-1很可能通过激活肾小管上皮细胞Wnt/β-catenin通路导致肾纤维化。我们前期在人尿蛋白质组学研究中发现,尿Mucin-1肽段与肾功能相关,但Mucin-1影响肾功能的机制尚未被阐明。本项目将在前期研究基础上,探讨:1)在SHR大鼠及β-catenin基因敲除小鼠中,Wnt/β-catenin通路介导Mucin-1导致肾纤维化过程;2)在肾小管上皮细胞中,Mucin-1/Wnt/β-catenin通路参与肾小管上皮细胞EMT机制;3)在高血压人群中,血、尿Mucin-1水平在慢性肾损伤中的作用。
英文摘要
Kidney is an important target organ of hypertension. Mucin-1 is highly expressed in the renal tubular epithelial cells and might cause epithelial-mesenchymal transition (EMT), resulting in renal fibrosis. Overexpress of Mucin-1 or Galectin-3 might activate Wnt/β-catenin signal passway which is associated with the increase of the EMT effector in cancer cells. Mucin-1 might induce renal fibrosis by activating Wnt/β-catenin pathway in the renal tubular epithelial cells. Our previous urinary proteomics study showed that urinary Mucin-1 subunit is associated with renal function in human while the mechanism is not demonstrated. Based on previous studies, this project will investigate: 1) In SHR rats and β-catenin knock-out mice, the progress of Wnt/β-catenin pathway in renal fibrosis caused by Mucin-1; 2) In renal tubular epithelial cells, the mechanism of Mucin-1/Wnt/β-catenin pathway in the EMT of renal tubular epithelial cells; 3) In hypertensive patients, the role of serum and urinary levels of Mucin-1 in renal damage.
期刊论文列表
专著列表
科研奖励列表
会议论文列表
专利列表
DOI:--
发表时间:2023
期刊:American Journal of Hypertension
影响因子:--
作者:Huang Qi-Fang;Cheng Yi-Bang;Guo Qian-Hui;Wang Ying;Chen Yi-Lin;Zhang Dong-Yan;An De-Wei;Li Yan;Wang Ji-Guang
通讯作者:Wang Ji-Guang
DOI:10.1161/hypertensionaha.120.14591
发表时间:2021-03
期刊:Hypertension (Dallas, Tex. : 1979)
影响因子:--
作者:Huang QF;Yang WY;Asayama K;Zhang ZY;Thijs L;Li Y;O'Brien E;Staessen JA
通讯作者:Staessen JA
DOI:10.1080/08037051.2022.2154745
发表时间:2022-12
期刊:Blood Pressure
影响因子:1.8
作者:Jing Xie;Qi-Fang Huang;Zhihan Zhang;Y. Dong;Haimin Xu;Yanan Cao;C. Sheng;Yan Li;Chaofu Wang;Xuefeng Wang;Ji-Guang Wang
通讯作者:Jing Xie;Qi-Fang Huang;Zhihan Zhang;Y. Dong;Haimin Xu;Yanan Cao;C. Sheng;Yan Li;Chaofu Wang;Xuefeng Wang;Ji-Guang Wang
Cardiovascular End Points and Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components
心血管终点和死亡率与中枢脉动血压成分的相关性并不比外周脉动血压成分更密切
DOI:10.1161/hypertensionaha.120.14787
发表时间:2020-08-01
期刊:HYPERTENSION
影响因子:8.3
作者:Huang, Qi-Fang;Aparicio, Lucas S.;Staessen, Jan A.
通讯作者:Staessen, Jan A.
DOI:10.1161/hypertensionaha.121.18773
发表时间:2022-05
期刊:Hypertension (Dallas, Tex. : 1979)
影响因子:--
作者:Cheng YB;Thijs L;Aparicio LS;Huang QF;Wei FF;Yu YL;Barochiner J;Sheng CS;Yang WY;Niiranen TJ;Boggia J;Zhang ZY;Stolarz-Skrzypek K;Gilis-Malinowska N;Tikhonoff V;Wojciechowska W;Casiglia E;Narkiewicz K;Filipovský J;Kawecka-Jaszcz K;Wang JG;Li Y;Staessen JA;International Database of Central Arterial Properties for Risk Stratification (IDCARS) Investigators
通讯作者:International Database of Central Arterial Properties for Risk Stratification (IDCARS) Investigators
AGEs-MAPK-ENaCs信号通路在高血压水盐代谢中的调控作用及机制
  • 批准号:
    81400312
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    23.0万元
  • 批准年份:
    2014
  • 负责人:
    黄绮芳
  • 依托单位:
国内基金
海外基金