维氏气单胞菌是水产养殖中危害极大的致病菌，其致病机理还不完全清楚，已发现III型分泌系统（T3SS）在致病中起重要作用。我们近期结果提示，转移信使RNA（tmRNA）和双组分调控系统（Bvgs-RR），对T3SS效应蛋白AexU均存在调控作用。在前期研究获得有利证据基础上，我们提出了一个新的致病作用模型，即tmRNA、Bvgs-RR、AexU可能构成一条致病信号通路。本研究拟采用基因过表达、RNA与调控区的相互作用分析等方法，证实tmRNA对Bvgs-RR的调控方式，明确它们在信号传递中的调控关系。这对于丰富tmRNA的表达调控理论有积极的意义，也为系统研究维氏气单胞菌的致病机制奠定基础，并为寻找细菌性疾病的治疗靶点提供技术支持。

Aeromonas veronii is a kind of important pathogens which can cause the massive death of aquatic animal. Although it is hard to figure out the comprehensive understandings of pathogenic mechanism, some researches reveal that Type III Secretion system （T3SS）play a crucial role in the pathogenic process.Our preliminary work showed that both transfer-messenger RNA （tmRNA）and Bvgs-RR which represented as one of the two-component system regulons could regulate the expression of effector protein AexU of T3SS.Here we propose a pathogenicity model that tmRNA and Bvgs-RR and AexU constitute a pathogenic signal pathway. By gene overexpression, RNA and regulation region interactions, the regulation pattern between tmRNA and Bvgs-RR would be characterized.These results would facilitate to enrich the thory of tmRNA expression and regulation, and uncover the pathogenic molecular mechanism of Aeromonas veronii, and are also helpful to seek for the therapeutic targets for bacterial diseases.