夜发性额叶癫痫(nocturnal frontal lobe epilepsy, NFLE)起源于额叶且与睡眠相关，临床表现多样，普通影像学技术难以发现异常，早期诊断困难。研究发现NFLE在额叶存在γ-氨基丁酸(GABA)网络代谢和功能的异常，但其起源及衍变的机制不清。我们的前期研究已经成功应用1H-MRS技术，在恒河猴癫痫模型的基础上，定量检测出丘脑区域GABA浓度的变化，并发现GABA浓度波动后持续性降低与其发展成为慢性癫痫相关，据此假设NFLE早期亦存在GABA网络代谢及功能异常，且与预后相关。因此，我们拟应用1H- MRS技术，动态跟踪研究40例新诊断的NFLE患者脑区的GABA水平并进行定量测定，研究GABA网络与NFLE发生发展的相关关系，探讨NFLE中GABA网络异常发生及衍变特征，深入对NFLE发生机制的认识，寻找早期分子影像学预警指标，为定量动态监测和调控治疗提供理论依据

Nocturnal frontal lobe epilepsy (NFLE) predominantly occurs during sleep with the origin of frontal lobe. The clinical semiologies of NFLE are generally variable without detectable lesions in routine imaging, which lead to the difficulty of early diagnosis. Previous studies indicated that the GABAergic neuronal network of frontal lobe was involved in NFLE, but the underlining mechanism of epileptogenesis and development are still unclear. Our previous study has already successfully applied quantitative measurment by 1H MRS into Coriaria Lactone-induced rhesus monkey model, which found the fluctuation of GABA concentration in thalamus and the continuous decrease afterwards related to the chronic epilepsy. Based on these findings, the hypothesis of the association between the dysfunctional GABAergic neuronal network and the mechanism of epileptogenesis in early phase of NFLE, as well as the prognosis has been proposed. Thus, this study aims to investigate the quantitative level of GABA dynamically in frontal lobe among 40 patients with newly diagnosed NFLE by mature techniques of 1H MRS, in order to find out the correlation in GABAergic network and the epileptogenesis of NFLE, explore the characters of abnormal GABAergic network and its evolvement, deepen the understanding of underling mechanism, search the imaging index for early warning prediction，and provide the theoretical evidence for further treatment in NFLE.