体外心脏震波治疗缺血性心力衰竭的作用机制

缺血性心力衰竭（IHF）已成为人类心脏疾病死亡的主要原因之一，探索IHF治疗新方法及其显效机理已成为医学界研究的热点及难点。目前国内外研究报道，心脏震波治疗（CSWT）是一种无创、安全、有效的IHF新疗法，但其显效机制尚未完全明确。本项目将在前期研究基础上（CSWT能促进缺血心肌毛细血管再生及侧枝循环建立），从细胞和动物两个层面上，即乳鼠心肌细胞和大鼠IHF模型上，实验验证CSWT是否通过激活PI3K/Akt和ERK1/2信号通路而发挥抑制心肌细胞凋亡及心肌纤维化效应,揭示CSWT治疗IHF的显效机理。本项目研究将为CSWT治疗IHF提供实验基础及理论依据，将为CSWT在临床的推广应用提供科学依据，具有重要的临床应用价值及意义。

Ischemic heart failure (IHF) has become one of the major causes of death in human heart disease,To explore the new treatment of IHF and illuminate its effective mechanism has become the hot and difficult focus in the medical field. At present, the domestic and foreign experts report that extracorporeal cardiac shock wave therapy (CSWT) is a non-invasive, safe, effective and new treament of IHF, but its effective mechanism is still not completely clear. This project will be based on the previous study to illuminate that CSWT can inhibit yocardial apoptosis and myocardial fibrosis through PI3K/Akt and ERK1/2 signal transduction pathway by used the cells and animals，to reveal the effective mechanism of CSWT in the treatment of IHF. This project will provide the experimental foundations and theoretical basises for the treatment of CSWT in IHF, and will provide a scientific basis for the widely used of CSWT in clinic. It will has important clinical application value and significance.