慢性萎缩性胃炎（CAG）的癌变与肿瘤的炎性微环境密切相关。长期慢性非可控性炎症持续作用于胃黏膜细胞，产生多种肿瘤相关细胞因子，形成肿瘤微环境，从而导致胃黏膜细胞的癌变。如何改善或逆转CAG伴癌前病变成为目前研究的热点及亟需解决的问题。前期研究提示，胃萎清能有效改善胃黏膜病变情况，缓解CAG患者胃部症状，改善患者的生存质量。此外，胃萎清能在一定程度上改善大鼠胃黏膜超微结构、萎缩及肠上皮化生。通过前期研究，我们提出以下科学假说：胃萎清能改善CAG患者及大鼠胃粘膜的病理情况，可能通过调控炎-癌转化过程中的信号通路，从而调控关键肿瘤免疫细胞因子，预防由炎向癌的转化。为了阐明科学问题，拟开展以下研究：筛选参与“炎-癌”转化过程的肿瘤免疫细胞因子；验证肿瘤免疫细胞因子；胃萎清对肿瘤免疫细胞因子的调控机制。本项目的顺利实施将为CAG的炎-癌转化确立潜在的调控因子，从更深层面揭示CAG治疗的分子机制。

Chronic atrophic gastritis (CAG) is closely related to the inflammatory microenvironment of tumors. Chronic uncontrollable inflammation continues to act on gastric mucosal cells, producing a variety of tumor-related cytokines, forming a tumor microenvironment, leading to cancer of gastric mucosal cells. How to improve or reverse CAG with precancerous lesions has become a hot research topic and an urgent problem to be solved. Previous studies suggest that Weiweiqing can effectively improve gastric mucosal lesions, alleviate gastric symptoms and improve the quality of life of CAG patients. In addition, Weiweiqing can improve the ultrastructure, atrophy and intestinal metaplasia of gastric mucosa in rats to some extent. Through previous studies, we proposed the following scientific hypothesis: Weiweiqing can improve the pathological condition of gastric mucosa in CAG patients and rats, possibly by regulating the signaling pathway in the process of inflammation-cancer transformation, thus regulating key tumor immune cytokines, and preventing the transformation from inflammation to cancer. In order to clarify the scientific issues, the following research will be carried out: screening tumor immune cytokines involved in the process of "inflammatory-cancer" transformation; verifying tumor immune cytokines; regulating mechanism of Weiweiqing on tumor immune cytokines. The successful implementation of this project will establish potential regulatory factors for CAG inflammation-cancer transformation and reveal the molecular mechanism of CAG treatment in a deeper level.