泪膜动态光学质量与连续性功能性视力同步实时分析系统的构建与应用研究

干眼是临床上常见的眼表疾病，泪膜稳定性的丧失是其核心的病理生理学改变。干眼患者常由于泪膜不稳定而引起眼表不规则，泪膜光学质量下降，从而出现视觉干扰。泪膜的形态不是静止的，时刻处于动态变化中，因此对泪膜质量也应进行动态分析。本项目旨在构建稳定的泪膜动态光学质量与连续性功能性视力同步实时分析系统，实现泪膜稳定性主、客观同步实时评估，并对测量结果进行参数化定义，获得泪膜评价新指标。并应用该系统提供的相关参数分析评价干眼患者，实现该系统的初步临床应用，完善干眼的临床评价体系，从而在临床中为干眼综合征的诊断、随访、治疗方法的评价以及主观症状的解释提供新方法、新思路。

Dry eye disease (DED) is a common ocular surface disease in clinic. The loss of homeostasis of the tear film is the core pathophysiological change. The patients with DED often possess irregular ocular surface due to the instability of tear film, which decreases the optical quality of the tear film and then leads to significant visual disturbances. The morphology of the tear film changes constantly, therefore, the dynamic analysis of the tear film should be carried out. The purpose of this study is to develop a stable synchronous real-time system for tear film optical quality dynamics analyzing and continuous functional visual acuity measuring, this can achieve a subjective and objective assessment of tear film stability in the synchronous real-time base. The parameters of the measured results were parameterized and the new indexes for tear film assessment were obtained. The relevant parameters of the system are applied to evaluate the patients with DED, the preliminary clinical application of the system is implemented, this will improve the clinical evaluation system of DED. Therefore, a new method and new idea are provided for the diagnosis, follow-up, evaluation of treatments and the interpretation of subjective symptoms for DED in clinical practice.