中医治疗糖尿病肾病（DN）优势特色显著。课题组前期研究证实肾络瘀阻是DN病机演变的关键环节。三棱—莪术作为活血消癥代表药对，广泛用于DN临床。作为心血管事件高危人群，DN患者常使用阿司匹林（ASA）进行冠心病预防。二者联用是否加重胃粘膜损伤导致消化道出血风险增加这一关键临床问题亟须阐释。根据文献报道，COX/LTs/NF-κB信号通路在ASA导致的胃黏膜损伤中发挥重要调节作用；三棱-莪术可通过调控NF-κB通路减轻胃黏膜病变。据此申请者提出三棱—莪术通过调控COX/LTs/NF-κB通路，在治疗DN肾纤维化的同时，改善ASA诱导胃黏膜损伤的假说。本研究应用免疫组化、qPCR等技术，通过体内、外研究明确三棱—莪术对ASA诱导DN胃黏膜损伤的干预作用，以COX/LTs/NF-κB通路为核心开展其作用靶标的深入研究，阐明二者联合用药减轻胃粘膜损伤的分子机制，为临床合理用药提供科学依据。

Traditional Chinese medicine has certain advantages in treatment of diabetic nephropathy (DN). Our previous studies confirmed that kidney stasis is the key link in the pathogenesis of DN. Rhizome Sparganii & Rhizoma Curcumae is a representative drug pair for promoting blood circulation and eliminating disease, and is widely used in clinic treatment of DN. As a high-risk group of cardiovascular events, DN patients often use aspirin (ASA) for coronary heart disease prevention. Whether the combination of the two will aggravate gastric mucosal damage leads to increased risk of gastrointestinal bleeding is a critical clinical issue that needs to be clarified. According to the reports, the COX / LTs / NF-κB signaling pathway plays an important regulatory role in the gastric mucosal damage caused by ASA; Rhizome Sparganii & Rhizoma Curcumae can relieve gastric mucosal injury by regulating the NF-κB pathway. Based on this, it is proposes that the Rhizome Sparganii & Rhizoma Curcumae by regulating the COX / LTs / NF-κB pathway, while treating DN renal fibrosis, improves the hypothesis that ASA induces gastric mucosal damage. In this study, STZ + unilateral nephrectomy DN rat model was used, with immunohistochemistry, qPCR and other techniques, were used to determine the intervention effect of Rhizome Sparganii & Rhizoma Curcumae on ASA-induced DN gastric mucosal injury through in vivo and in vitro studies. The COX/LTs/NF-κB pathway was used as the core to develop its target Research to clarify the molecular mechanism of the combined use of the two drugs to reduce gastric mucosal damage and provide a scientific basis for the rational use of drugs in the clinic.