树突状细胞（DC）等免疫细胞在形成白血病微环境、影响白血病发展中发挥重要作用。非感染性炎症反应参与疾病微环境的形成，在多种疾病发挥作用，但在白血病微环境中的作用机制鲜有报道。在国自然课题资助下，我们从非感染性炎症反应角度解读白血病微环境形成过程，发现干扰素调节因子7（IRF7）发挥重要作用并影响白血病进展。本课题提出白血病微环境DC细胞中IRF7在形成白血病相关的非感染性炎症微环境及影响白血病进展中发挥重要作用。通过构建DC细胞Irf7基因条件敲除小鼠急性白血病模型，深入阐明DC细胞中Irf7基因在形成白血病微环境中的作用机制及对白血病进展的影响，探索通过干预DC细胞IRF7表达及活性提高抗白血病作用的手段，更深入地阐明白血病微环境形成机制和在白血病发展中的作用和意义，完善微环境因素对肿瘤、白血病作用机制，具有重要理论意义；同时为寻找白血病治疗的新策略和靶点提供线索，具有潜在应用前景。

Immune cells such as dendritic cells (DCs) play important roles in development of leukemic microenvironment and progression of leukemia. Sterile inflammation takes part in the development of disease microenvironments and plays pathological roles in many diseases. However, its role in leukemic microenvironment has not been well established. During the study for the previous NSFC grants, we first studied the development of leukemic microenvironment from the sterile inflammation point of view. We found that interferon regulatory factor 7 (IRF7) played important roles in this process and affected leukemia progression. Based on our previous results, we propose that IRF7 in DCs in leukemic microenvironment plays important roles in the development of leukemia-related sterile inflammation and affecting leukemia progression. By the establishment of mouse acute leukemia model in mice with Irf7 gene conditional knockout in DCs, we will study the mechanism of Irf7 gene in DCs on the development of leukemia microenvironment and the progression of leukemia. We will also explore anti-leukemia methods by interfering the expression and activation of IRF7 in DCs. This study will not only enable us to further understand the role and significance of leukemic microenvironment on the development of leukemia, as well as the mechanism of microenvironmental factors on tumors and leukemia, but also provide clues for further study searching for new strategies and targets for the treatment of leukemia.