上转换/半导体复合纳米材料可在近红外光下用作诊疗一体化的纳米药物，在生物医学上具有广阔的应用前景。开发新型的全无机、结构稳定、种类和成份可调的复合纳米材料，并探索其内在工作机制，是该领域当前急需解决的科学问题之一。在本项目中，我们提出将上转换纳米晶和MOF材料有机结合并构建成使用近红外光驱动的复合材料的构想，为将MOF材料应用于生物活体组织提供了一个新思路。同时，我们拟利用MOF容易模板衍生成各种无机半导体材料（及固溶体）的独特优点，获得一系列种类及成份可调的上转换/半导体复合纳米材料。通过对半导体材料的种类和成份的调控，我们可选择性获得不同的表面活性物种，从而调控其光氧化性能。通过对这类材料的内在构成、工作机制及物理性能的系统探索，我们有望开发出高效的、近红外光驱动且性能可控的复合纳米材料，并应用于光催化氧化、PDT抗菌及抗肿瘤等领域。

Upconversion/semiconductor nanocomposites can serve as theranostic nanomedicines under near-infrared (NIR) light, showing promising applications in biomedical engineering. Development of novel all-inorganic, stable, component-tunable nanocomposites and exploring their intrinsic working mechanism are key scientific problems in this research filed. In this project, we bring forward a new idea to integrate upconversion nanoparticles (UCNs) with metal-organic frameworks (MOFs) semiconductor materials. The proposed nanocomposites can be driven by NIR light and enable the MOFs for deep biological tissue application. At the same time, we can derive a series of component-tunable UCN/semiconductor nanocomposites from the UCN/MOFs, since the MOFs can be facilely converted to various inorganic semiconductors (or solid-solution phases). By tailoring the types and/or components of the semiconductor shells, different ROS species can be selectively generated from the nanocomposites. Therefore, we will be able to regulate the photo-oxidation properties of these nanocomposites. The deep exploration of the inner compositions, working mechanism and physical properties of these materials will help us to develop efficient, NIR-driven and property-controllable nanocomposites and apply them in various fields such as photocatalytic oxidation, PDT antibacterial and antitumor.