lncXR_429159.1通过NET通路调控SCLC脑转移的机制及作为脑转移风险预测标志物的研究

小细胞肺癌脑转移的发生率超过50%，预防性脑照射（PCI）是普遍采用的降低脑转移率的有效方法，但并不是所有患者都能获益，不加选择的对所有疗效为CR和PR的SCLC患者进行PCI会影响长期生存患者的生活质量。精准预测SCLC的脑转移风险是规避上述不足的有效方法，但目前仅依靠临床分期及血清标志物等少数指标，亟待寻找新的标志物。深入了解SCLC脑转移的机制有助于发现新的标志物。我们前期研究发现，lncRNA XR_429159.1是调控SCLC转移的重要分子，其作用与NET通路有关，而且血清水平与脑转移风险显著相关。本项目拟利用现代细胞分子生物学技术，对lncRNA XR_429159.1通过NET通路调控SCLC脑转移的机制及作为脑转移风险预测标志物的价值进行研究，不仅有助于了解SCLC的转移机制，而且有可能发掘潜在的阻断脑转移的治疗靶点，并发现新的脑转移风险预警标志物。

The incidence of brain metastasis in small cell lung cancer is more than 50%. Prophylactic cranial irradiation (PCI) is a widely used and effective method to reduce the rate of brain metastasis, but not all patients can benefit from it. Non-selective PCI for all SCLC patients with CR and PR will damage the quality of life of long-term survival patients. Accurate prediction of brain metastasis risk of SCLC is an effective method to avoid the above shortcomings. But at present, only a few indicators such as clinical stage and serum markers are used in clinical work, and it is urgent to find new markers. An in-depth understanding of the mechanism of SCLC brain metastasis is helpful to find new markers. Our previous study found that lnc XR_429159.1 is an important molecule regulating SCLC metastasis, its role is related to NET pathway, and serum levels are significantly related to the risk of brain metastasis.This project intends to use modern cellular and molecular biological techniques to study the mechanism of lncXR_429159.1 regulating SCLC brain metastasis through NET pathway and its value as a marker for predicting the risk of brain metastasis, which is not only helpful to understand the metastasis mechanism of SCLC, but also possible to explore potential therapeutic targets to block brain metastasis and to find new early warning markers of brain metastasis risk.