天然产物及其抗肿瘤活性研究已成为国内外研究热点，天然产物在新药及新药先导化合物研究中占有不可替代的作用，越来越受到人们的关注。该项目可望取得海洋红树伴生植物相思子次生代谢产物新结构。围绕"红树伴生相思子特有活性次生代谢"关键科学问题，选择我国特有红树环境生态系统的相思子，发现具有生理与生态学效应的新颖次生代谢产物，研究药理作用机理，从而为创新药物和特色环保制品的开发奠定基础。前期研究结果表明：多个单体化合物表现出抗MCF-7，Hela，SW1990及Du-145肿瘤细胞活性。本项目拟在现有研究基础上，综合利用天然产物化学与药理学原理与方法，色谱分离及波谱分析技术，充分挖掘红树伴生相思子的抗肿瘤细胞活性次生代谢产物。据文献调研：红树伴生相思子代谢产物研究未见报道。

Research on natural products and their antitumor activity has become a hot topic and natural products play an irreplaceable role in the study of lead compounds and new drugs.The project is expected to acquire new secondary metabolites of mangrove associated A. precatorius. Around the key scientific problem of " mangrove associated A.precatorius unique active secondary metabolism ",we choose mangrove ecosystem A. precatorius to discove novel secondary metabolites with physiological and ecological effects.We have researched on the chemical constituents of A.precatorius collected from the mangrove wetlands of Hainan Island, China and our preliminary research results indicate that: many of the compounds revealed antibacterial and cytotoxicity activities against MCF-7,Hela,SW1990 and Du-145 tumor cells. Based on the previous work, by utilization of cross discipline of natural product chemistry and pharmacology and techniques of chromatographic and spectral analysis, this project intends to dig out the functional secondary metabolites from Hainan mangrove associated plant A.precatorius,and study their antitumor activity, According to the literature review, researches on the active secondary metabolites of mangrove associated A.precatorius are not been reported.