生物质来源的蔗渣木聚糖具有独特的生物活性，其抗癌活性作用尤为引人关注。研究发现蔗渣木聚糖的丙烯酰胺接枝共聚物具有一定的抗癌作用，但其是否具有成药性尚未可知。本课题拟在前期构建合成的3种蔗渣木聚糖接枝丙烯酰胺类共聚物基础上，基于已有的研究结果及计算机辅助药物设计法，与4-乙酰胺基肉桂酸、2-氨基喹啉、灵芝酸DM三种环状化合物通过接枝或接枝-酯化反应，分别引入第二种具有抗癌活性的分子或活性基团，设计构建9种具有高效抗癌活性的蔗渣木聚糖衍生物。并采用MTT、DAPI、Western Blot等方法对目标产物进行体外抗癌活性研究与分子模拟。继而结合纳米技术，以含二硫键单元的氨基功能化介孔硅为药物输送载体构建抗癌纳米新剂型，并对其药理性质、分子生物对接、药代分子动力学等成药性进行研究。该项目将为蔗渣木聚糖衍生物活性分子构建及其抗癌活性研究提供新思路，为抗癌靶向药物的临床应用奠定基础。

Bagasse xylan, a kind of biomass renewable resources, has unique biological activity, and its anti-cancer activity is particularly noteworthy. Recent studies show that bagasse xylan of acrylamide graft copolymer has some kind of anti-cancer effect, but whether it has druggability is not yet known. Three kinds of bagasse xylan graft acrylamide copolymer have been synthesized. Based on the existing research results and computer aided drug design method, through grafting or grafted - esterification reaction, this research can construct 9 kinds of bagasse xylan derivatives with high anticancer activity by introducing anti-cancer activity molecules or active functional groups which are three kinds of cyclic compounds (4 - acetamide cinnamic acid, 2 - amino quinoline, ganoderma lucidum acid DM). Then, the anticancer activity of them will be tested by MTT method, DAPI fluorescence stain method, Western Blot analysis method. The new dosage will be select and research on its druggability, including physical and chemical properties of drugs, molecular biological docking, pharmacokinetics and harmful side effects, which is a new anticancer dosage produced by nanotechnology, combined with the product-loaded nanoparticle and the carrier which is contained disulfide bond unit of amine functionalized mesoporous silica. The project will provide new research ideas on the biological activity of the bagasse xylan and lay the foundation for developing its as anti-cancer dosage in the clinical application.