骨巨细胞瘤（GCTB）是临床常见的原发骨组织肿瘤之一，发病机制尚不明确，其侵袭性及复发率高是治疗该疾病的难题之一。目前关于GCTB中Micro -RNA的研究仍很少，我们的前期研究结果表明MicroRNA-210、低氧诱导因子-1α表达异常与GCTB存在关联，但确切调控机制不明。基于此，提出如下假：OPG/RANK/ RANKL在GCTB的发生发展中具有重要作用，ODF、RANK与RANKL的蛋白及mRNA的高表达，OPG的蛋白及mRNA的低表达，促进了GCTB的发生发展，而MicroRNA-210可以通过调控OPG/RANK/ RANKL信号通路，对GCTB形成进行有效抑制。通过基因转染、RT-PCR、Western blot等实验技术检测OPG/RANK/ RANKL信号通路相关因子表达。研究骨miRNA在GCTB发生与发展机制中作用，并为其临床诊断和治疗提供新的靶点。

Giant cell tumors of bone (GCTB) is one of the most common primary bone tumors, its pathogenesis is unclear,locally aggressive and recurrence rate is high is one of the problem in clinical . The research on Micro - RNA in GCTB is still rarely, our previous studies have shown that the mirna - 210, hif - 1 alpha expressing anomalies associated with GCTB exists, but the exact regulatory mechanism is unknown. Based on this, puts forward the following false: OPG/RANK/RANKL plays an important role in developing GCTB ODF, RANK and high protein and mRNA expression of RANKL and OPG protein and lower expression of mRNA, promoted the development of the GCTB, and mirna - 210 can through regulating OPG/RANK/RANKL signaling pathways, to effectively restrain GCTB formation. By gene transfection, rt-pcr, Western blot experimental techniques such as detection of OPG/RANK/RANKL signaling pathways related factor expression. Believe in giant cell tumor of micrornas can study as we learn more about the giant cell tumor occurrence and development mechanism, and provide new targets for the clinical diagnosis and treatment.