广西壮族自治区高中及中职学校在校生血清戊型肝炎病毒IgG 抗体阳性率抽样调查

戊型肝炎是一种由戊肝病毒引起的常见传染病，近年我国戊肝报告病人数已超过甲肝,病情较甲肝严重。预防戊肝最有效的方式是接种疫苗。在我国，戊肝疫苗已于2012年获准上市。不同于其他肝炎疫苗，该疫苗规定其最低接种年龄不是0岁而是16岁。由于0-15岁人群有一部分已经感染过戊肝并且获得了免疫力，因此了解16岁年龄段的戊肝群体免疫水平基线资料，对当地政府相关部门判断有无必要对该人群中进行集中、大规模的疫苗接种以预防戊肝流行有非常重要的参考意义。但我国非常缺乏这个年龄段人群的戊肝抗体流行率的研究。我国高中及中职学校在校生年龄正好是16-18岁左右，因此本研究拟以2015年9月-2016年7月所有广西高中在校学生为对象，进行分层、随机、多阶段、整群抽样，对被抽中的学生采血检测抗-HEV IgG，从而测算该群体的抗-HEV IgG流行率，为今后有关政府部门制定戊肝防制策略和措施提供科学依据。

Hepatitis E is a common infectious disease caused by the hepatitis E virus (HEV). The number of reported patients with haptitis E in our country has exceeded hepatitis A and hepatitis E is more serious than hepatits A. the most effective way to prevent hepatitis E is using vaccine. In China, hepatitis E vaccine has been approved in 2012. Unlike other hepatitis vaccine, with safety considerations, the minimum age for vaccination is not 0 but 16 years old. Because a part of children aged 0-15 year-old are already infected with HEVand acquired immunity, the baseline data of herd immunity to HEV infection in 16 years-old age is very important for the local government to determine whether there is a need for vaccination by concentration and large scale to prevent hepatitis E epidemic in this population. However,our country lacks the studies of HEV antibody prevalence in this age group. The high school students is 16-18 years old and crowded, so this study intends to investigate the prevalece of anti-HEV IgG in high school students during 2015 September - 2016 July inGuangxi ,through a stratified, random, multi-stage, cluster sampling. The students will be tested for anti -HEV IgG. The results will provide a strong scientific basis for the government to formulate control Strategy and measures for HEV infection.