术后腹膜粘连是指腹膜受到手术损伤与刺激后在脏器间、脏器与腹壁间产生的纤维性粘连。术后腹膜粘连在腹盆腔手术中发生率达90%，迄今为止，腹盆腔疾病术后粘连的相关研究均缺乏系统与深入研究，不管是基础、应用基础还是临床应用研究，几乎是空白。因此，开展术后粘连的相关基础研究，特别是该疾病发生、形成与发展过程中的分子机制，是解决这一复杂问题的根本。本项目拟在前国家自然科学基金（中药常通口服液对术后粘连成纤维细胞分子药理学作用机制研究，NO：30873271）研究基础上，进一步深入研究TGF-β/Smads和NF-κB/Rho/Rho-kinase信号转导通路所扮演角色，探寻他们之间交叉对话及相应调控靶点，从分子学角度揭示粘连发生过程中炎症反应、腹膜纤溶活性、伤口愈合等不同环节对术后粘连所表现出来的作用，为后期防治术后腹膜粘连提供新的防治策略和靶点，对以术后粘连为代表的腹膜病变具有一定启发性和指导意义。

Postoperative peritoneal adhesions, which occur in the peritoneal cavity as a result of surgery or stimulation of foreign body, are the most frequent complication of abdominal surgery. Up to now, The research in this erea is still lack of intensive study, whether in foundation or application areas, especially in the erea of clinical therapy. Therefore, in order to solve this complicated problem, it is necessary to carry out the postoperative adhesion related basic research, especially the disease occurrence and the molecular mechanism in the formation and development process. Our proect is founded on the previous National Natural Science Foundation of China(The effect of traditional Chinese medicine Changtong Oral Liquid（CTOL） on the fibroblast cells derived from postoperative adhesion.No:30873271). The purpose of this study is to develop the roles of TGF-β/Smads and NF-κB/Rho/Rho-kinase signaling pathways in postoperative peritoneal adhesions and find their corresponding cross-talk binding sites, in order to reveal the relationship between inflammatory response, wound healing and fibrinolytic activity from the point of molecular studies in vivo and in vitro.These studies may have an enlightening and guiding significance for prevention and treatment in postoperative peritoneal adhesions and other peritoneal lesions.