目前认为痛风的发生主要与白介素相关因子导致的炎症级联反应有关 ，但确切机制尚未阐明。本课题组前期研究发现新疆不同民族尿酸水平、高尿酸血症的发病率存在差异，对汉族和维吾尔族高尿酸血症患者I白介素相关基因和TGF-β相关基因的大样本检测发现存在民族差异，而高尿酸血症最直接导致的临床病患就是痛风，因此该基因位点的功能区突变导致的基因转录和蛋白表达异常可能与痛风的炎症反应诱发存在一定的联系。基于此假设,本研究拟采取目标区域捕获技术对新疆维、汉男性民族痛风患者和正常对照人群白介素相关基因与TGF-β基因启动子区差异研究进行验证，从功能研究的角度探讨痛风发病分子机制及深层次机理以及维汉民族尿酸代谢差异的遗传学机制，为痛风特异性防治提供新的靶点。

At present, the occurrence of gout is mainly related to interleukin-related factors caused by inflammation cascade, but the exact mechanism has not yet elucidated. In this study, we found that the incidence of uric acid and the pathogenesis of hyperuricemia were different in different ethnic groups in Xinjiang. There were significant differences in the correlation between interleukin-related genes and TGF-β-related genes in Han and Uygur patients with hyperuricemia , And hyperuricemia is the most direct cause of clinical patients is gout, so the functional site of the gene mutation caused by gene transcription and protein expression abnormalities may be associated with gout inflammatory response induced by some contact. Based on this hypothesis, this study intends to take the target regional capture technique to identify the differences in interleukin-related genes and TGF-β gene promoter regions between Xinjiang and Han national gout and normal control population. From the perspective of functional research, Mechanism and deep mechanism and the genetic mechanism of uric acid metabolism in Weihan nationality, and provide a new target for gout prevention and control