在高分子仿酶研究中，如何更好地模拟天然生物大分子设计制备出能与天然酶相媲美的仿酶体系一直都是这一领域的重要科学问题。此前报道的只有生物聚合物，如蛋白质和核酸，才能够表现出十分精致有序的折叠结构。. 本项目中我们应用聚合物化学与超分子化学，通过对自组装结构单元（功能化的1,3,5-三酰胺苯）、有机催化结构单元（功能化的L-脯氨酸）以及温度响应性结构单元（N-异丙基丙烯酰胺）的巧妙构思，设计了一个接枝温度响应性PNIPAM的水溶性三元无规共聚物大分子，研究该聚合物大分子如何通过分子内自组装完成将单个聚合物链折叠成热响应性的聚合物纳米反应器。以对硝基苯甲醛、环己酮为底物的Aldol反应为模型，我们还研究不同温度下的水相不对称Aldol反应中，温度响应性PNIPAM侧链如何可逆地、动态地调节自组装纳米反应器的构象，如何可逆可控地调节纳米反应器的催化性能和回收再循环。

How to artificially design a system that is comparable to native enzymes by mimicking natural biological macromolecules, is an importantly scientific research issue in biomimetic catalysis. It has been reported that only biopolymers, such as proteins and nucleic acids, could fold up into stable conformations precisely and orderly.. In this project, by using of polymer chemistry and supramolecular chemistry, we skillfully design a water-soluble random terpolymer grafted with thermoresponsive structural units (N-isopropyl acrylamide, NIPAM) by combination of self-assembled structural units (functionalized benzene-1,3,5-tricarboxamides, BTA), and an organocatalytic structural units (functionalized L-proline). We study on how the grafted random copolymers fold into responsive single-chain polymeric nanoreactors via intramolecular self-assembly of pendant BTAs. . Besides, the catalytic activities of the single-chain polymeric nanoreactors will be investigated with aldol reaction by use of p-nitrobenzaldehyde and cyclohexanone in water. Furthermore, the investigations of how thermoresponsive PNIPAM dynamically regulate the conformations of nanoreactors, and how thermoresponsive PNIPAM reversibly control the catalytic activities and recycling of these nanoreactors under different temperatures will also be carried out.