核磁共振成像是肿瘤检测的常用手段，如何提高其检测灵敏度和准确度一直是个难题，核磁造影剂的发展是解决该问题的有效途径。本项目以无背景信号干扰、可有效改善氟化物水溶性、氟信号可控的非包裹式氟化温敏脂质体造影剂为研究对象，结合传统质子成像和荧光成像，对非小细胞肺癌进行基础科学研究。具体内容包括：合成新型的、可同时进行氟成像和荧光成像的三氟甲基化荧光磷脂标记物；标记并制备生物相容性好、稳定性强、温度敏感、核磁造影效果优且能进行荧光成像并装载抗癌药物的氟化脂质体；研究该脂质体基本性质、作用机制、活体肿瘤检测及代谢。本项目旨在发展稳定、高效、安全的非包裹式氟类温敏核磁造影剂，温度控制的off到on式19F MRI结合1H MRI揭示更多肿瘤部位信息，有效提高核磁检测灵敏度及准确度，为癌症的无创实时检测、监测提供一种新方法，为癌症的治疗提供更多可靠依据。

MRI has become an integral part of medical diagnosis, especially for tumor detection, of which it is really a big challenge to improve the sensitivity and accuracy. Developing different MRI molecular probes makes great sense. This project develops a kind of new non-encapsulated fluorinated liposomal contrast agent, which has no 19F MRI background and good temperature response. Combined with 1H MRI and fluoresce imaging, basic studies of non-small lung cancer will be done here. The details contain construction of new Trifluoromethyl fluorescent lipid,labelling and preparation of good biological temperature sensitive MRI liposome, liposome characterizations, tumor detection and metabolism. This project aims to develop a new kind of smart 19F MRI contrast agent with high efficiency and safety, lay the foundation for improving the sensitivity and accuracy of MRI detection, provide a new method for tumor detection and monitoring and give more reliable foundations to cancer therapy.