血管腔内技术的发展提高了糖尿病下肢缺血性疾病的治疗效果，然而术后再狭窄严重影响中远期疗效。腔内治疗在治疗疾病的同时，不可避免的造成新的血管内皮损伤。探讨血管内皮细胞损伤的机制，保护和修复内皮细胞功能，对改善预后有积极的意义。目前，针对糖尿病慢性下肢缺血介入治疗后再狭窄，缺乏切合临床过程的糖尿病下肢动脉慢性缺血、腔内介入治疗后动物模型。本研究尝试建立糖尿病、动脉硬化、慢性下肢缺血、腔内球囊损伤血管内膜动物模型，通过血管造影和病理观察证实模型的可靠性；在此基础上，应用理气活血配伍，针对糖尿病下肢缺血腔内治疗术后血管内皮功能损伤及炎症方面，观察理气活血配伍对高脂糖尿病慢性下肢缺血内皮损伤模型血管内皮功能保护及血管壁炎症反应抑制方面的干预作用，并从血管活性物质、蛋白、信号转导等方面进行机制探讨，为进一步研究理气活血配伍防治糖尿病下肢缺血性疾病血管腔内治疗后再狭窄提供部分实验基础。

With development of percutaneous transluminal angioplasty(PTA), there is enhanced clinical effect on chronic limb ischemia(CLI) in diabetes patients, while the restenosis after PTA play important role in the long term results. In the process of PTA, new endothelial injury is inevitable. The research of mechanism in endothelial injury, endothelial protection and recovery can raise the long term results in CLI after PTA.Although the restenosis is important for CLI in DM patients,Few animal models was designed for chronic low limb ischemia in hyperlipoidemia diabetes after artery PTA. In this research, rat model was designed for vascular endothelial injury with DM, angiosclerosis, CLI. Angiography and pathematology are applyed to confirm the dependability. After the establishment of rat model, Qi and activating blood compatibility is used, endothelial protection and inflammatory inhibition are observed, Also the vasoactive substance, proteinum, signial pathway. So, this experimental research of Qi and activating blood compatibility on endothelial protection in rat model with chronic low limb ischemia in hyperlipoidemia diabetes after artery percutaneous transluminal angioplasty can provide theoretical basis to the clinical research of vacular restenosis inperipheral artery.