本项目是按摩治疗单纯性肥胖机制研究的深入和完善，最新研究表明:下丘脑能量调节网络系统及脂肪细胞代谢紊乱可能是导致肥胖的病理基础，而AMPK信号调节通路在对机体能量代谢平衡起着至关重要的作用。课题组前期首先进行了按摩手法对肥胖模型大鼠的效应研究，并观察了部分神经生物学机制（整体效应机制），其次探讨了体外模拟手法力学刺激对(前)脂肪细胞的发育和内分泌功能影响（局部效应机制）。本研究旨在通过围绕"按摩通过抑制下丘脑AMPK 信号通路的活性，特异性地作用于下丘脑能量调节网络系统；并且激活外周AMPK 信号通路的活性，开启脂肪细胞代谢途径，从而调整机体能量代谢紊乱"的假说，运用功能磁共振（fMRI）、分子生物学等技术，探讨单纯性肥胖患者是否存在下丘脑能量平衡网络系统的异常，以及探明按摩治疗单纯性肥胖能量代谢平衡紊乱的机制，进一步深化按摩防治肥胖的机理研究，丰富临床应用按摩治疗单纯性肥胖的科学内涵。

This project is to penetrate and consummate the research mechanism of massage therapy on simple obesity. Latest researches indicate that the energy regulation network system of hypothalamus and metabolic disorders on adipocyte may be the pathological bases which result in obesity, while AMPK signal pathway plays a vital role in maintaining energy metabolism balance. The research group have firstly conducted effect studies of massage therapy on model of simple obesity rats and observed some neurobiological mechanism (whole effect mechanism), meanwhile, the team have discussed influences on the development of preadipocyte and function of endocrine with dynamic mechanical stimulation in vitro (local effect mechanism). This research aims at centering on the hypothesis that massage therapy can inhibit AMPK signal pathway's activity of hypothalamus and act on energy regulation network system of hypothalamus specifically; in addition, massage therapy can activate activity of peripheral AMPK signal pathway to open metabolic pathways of adipocyte, thus regulating the energy metabolic disorders. Then applying functional magnetic resonance imaging (fMRI) and molecular biology to explore whether patients with simple obesity exist abnormality on energy regulation network system of hypothalamus, ascertain mechanisms how massage therapy treat energy metabolism disorders of simple obesity, deepen mechanism study on how massage therapy prevent and treat obesity and enrich the clinical application's scientific connotation that massage therapy treat simple obesity.