钾通道在肝细胞癌发生发展中的作用

原发性肝细胞癌是我国常见的恶性肿瘤，预后差。细胞膜的离子通道在细胞功能的调节中起着重要的作用。研究表明钾通道与细胞增殖、凋亡等最基本的细胞生物学行为相关，提示钾通道可能涉及癌细胞的发生，但有关钾通道在肝细胞癌发生、发展中的作用未见研究报道。我们初步的研究发现钾通道Eag1、Kv1.3和Kca3.1在肝细胞癌异常表达,提示这些钾通道可能与肝细胞癌的发生、发展相关。在本项目中，我们将系统分析钾通道的表达与肝细胞癌临床病理特征和肿瘤复发转移的关系，再通过进一步的体内和体外研究阐明钾通道在肝细胞癌发生、发展中的作用及其细胞分子机制，以期为肝细胞癌的治疗提供新的治疗靶点，并为肝细胞癌预后的判断提供有意义的标志物。

Primary hepatocellular carcinoma (HCC) with a very poor prognosis is a common malignant tumor in our country. Membrane ion channels play an essential role in the maintenance of cell function. It has been shown that plasma membrane K+ channels are involved in fundamental cell behavior such as proliferation and apoptosis, indicating that K+ channels have a role in the development of cancer. However, the role of K+ channels in HCC remains unclear. Our preliminary study found the abnormal expressions of K+ channels , Eag1, Kv1.3 and Kca3.1, in HCC， indicating that the K+ channels may be involved in the development and progression of HCC. In the present study, we will further analyze the relationship between the abnormal expressions of K+ channels and clinico-pathological characteristics, recurrence and metastasis of HCC , explore the role of the K+ channels in the development and progression of HCC and reveal the cellular and molecular mechanism underlying. This project will contribute to providing a new target for the treatment of HCC and an important marker for the evaluation of prognosis of HCC.