肾上腺疾病常以激素分泌紊乱或实体肿瘤占位的形式对机体造成损害，在临床上较为常见。本课题申请人前期研究发现，与正常肾上腺相比，肾上腺肿瘤中类固醇生成因子-1（SF-1）表达升高，且SF-1影响肾上腺皮质激素对部分调控因素的敏感性。近期研究显示，ACTH通过与其受体ACTHR结合后，对SF-1和肾上腺疾病的致病发挥重要角色，ACTHR的作用远比传统认识更为广泛。以上述发现为基础，本课题应用人肾上腺皮质癌H295R细胞，研究SF-1、ACTHR不同表达水平对肾上腺皮质激素分泌和调控的影响，同时研究ACTHR在常见肾上腺肿瘤中的作用，揭示SF-1、ACTHR对肾上腺肿瘤成瘤机制及激素分泌调控的影响，进一步阐明其致病机理，为常见肾上腺疾病的治疗提供理论依据。

Adrenal diseases often cause body harm in the form of hormone disorders or solid tumor mass. It is more common in clinical practice. The applicant of this subject found that the expression of steroidogenic factor-1(SF-1) in adrenal tumor was elevated in compared with normal adrenal, and SF-1 altered adrenocortical hormone sensitivity to some regulatory factors. Recent studies have shown that ACTH played an important role in SF-1 and adrenal disease via combining to its receptor ACTHR. The role of ACTHR was wider than traditional understanding. Based on these findings, this application will investigate the effect of different SF-1 and ACTHR expression on adrenocortical hormone secretion and regulation using human adrenocortical carcinoma H295R cells, as well as ACTHR on common adrenal tumor. To reveal the influence of SF-1 and ACTHR on adrenal tumorigenesis and hormone secretion so as to further clarify its pathogenesis and provide a theoretical basis for the treatment of common adrenal disease.