急性湿疹是一种复发性、炎症性皮肤疾病，常伴有剧烈的瘙痒症状，严重影响了患者的生活质量。治疗该种疾病长期以来我们都使用了局部皮质类固醇激素制剂和免疫调节剂，但会出现皮肤萎缩、色素沉着等不良反应，不宜长期使用。前期我们通过大鼠实验以及临床实验，发现新鲜马齿苋溶液对绝大多数急性湿疹患者的瘙痒症状有明显抑制作用。但其具体有效成分以及其在治疗过程中关键调控因子和重要信号调控网络均尚未能明确。近年来研究表明，TRPV1在瘙痒发生机制中起着非常重要的作用。因此，结合中医“通因通用”学说，本实验提取马齿苋不同有效成分进行分组对比实验，从分子生物学的角度证实急性湿疹瘙痒症状与TRPV1痒信号通路导致局部“气血不畅”的关系，明确马齿苋活血消肿功能能够通过调控TRPV1阻断急性湿疹瘙痒通路，达到治疗疾病的目的。

Acute eczema is a recurrent, inflammatory skin disease, often accompanied with severe itching syndrome, which seriously influence patient's quality of life. For a long time, we used to use corticosteroid and immunomodulators, but it will appear skin atrophy, pigmentation and other adverse reactions, so, they can not be used for long-term. We have found fresh Ma Chi Xian has obvious inhibitory effect on the vast majority of patients with acute eczema itching from rat experiment and clinical experiment in the earlier experiment. But its effective components, the key in the treatment process of regulator and important signal regulatory networks are still not clear. Recently, so many studies show TRPV1 plays a very important role in the pathogenesis of itching, therefore, on the basisi of "treatment of obstructive disease with dredge way", the experiment use different Ma Chi Xian extracting, confirmed the relationship between acute eczema itching and "Qi Stagnation and Blood Stasis" by TRPV1 pathway fromthe molecular biology, to confirm that effective components of Ma Chi Xian can acute eczema itch pathway blockade by regulation TRPV1, which achieve the purpose of treating acute eczema