高承载低摩擦仿生结构高强度水凝胶的设计、制备及性能研究

高承载低摩擦的水凝胶仿生润滑材料作为关节软骨替代材料在生物医疗领域具有重要的应用前景。其间，具有优异力学性能的高强度水凝胶是制备高性能仿生润滑材料的理想选择。受生物体关节软骨固液双相特征及层状生化结构的启发，本项目拟通过仿生学设计理念，采用一种新颖的热辅助法快速高效地在本体高强度水凝胶表面构筑润滑层，制备出具有仿软骨型双层结构的高强度水凝胶功能材料，以实现高承载与低摩擦性能的统一。基于此，项目将系统研究仿生双层结构高强度水凝胶的化学组成、力学性能、形貌特征以及摩擦测试条件对材料的承载与润滑性能的影响，揭示其摩擦学特征与承载减摩机理，最终为设计新型水凝胶基仿生关节软骨替代材料提供技术支撑和理论依据。

Biomimetic lubrication materials based on hydrogels with high load-bearing and low friction properties show important application prospects in biomedical field as articular cartilage replacement. Meanwhile, the high strength hydrogels with excellent mechanical property provide an ideal choose for preparing biomimetic lubrication materials with good performance. Inspired by the bionics design concept of the solid-liquid biphasic feature and layered biochemical structure of articular cartilage, this project intends to quickly and efficiently engineer a lubricious layer on the surface of the high-strength hydrogel by adopting a novel heat-assisted method, which enables to the preparation of high strength hydrogels functional materials with cartilage-like bilayered structure to realize incommensurable properties of both high load-bearing and low-friction. Based on this, this project would systematic study the effects of chemical composition, mechanical properties and morphological features of the biomimetic bilayered high strength hydrogels, along with the tribological testing conditions, on its load-bearing and lubrication properties and then reveals the water-lubrication and load-bearing/friction-reducing mechanism. Finally, the study results would provide theoretical basis and technical support for developing novel hydrogel-based biomimetic materials as articular cartilage replacement.