阳离子肽与多阴离子的共组装是模拟特定生物结构，创造功能性材料的新途径，它在化学、生物及医药等领域具有重要的潜在应用。然而，当前研究面临的主要问题是多阴离子种类单一所导致的组装体协同功能开发不足。本项目拟将功能性无机多金属氧簇与阳离子肽结合构筑结构有序的新型超分子组装体。我们期望阳离子肽的自组装和手性特征与多金属氧簇的催化、荧光、光致变色等性质在组装体中实现整合和协同。同时，本项目将探索阳离子肽的抗菌性和药物传输性与多金属氧簇的生物活性间的互补关系。主要包括以下四部分：（1）设计、合成具有特定氨基酸残基的两亲性阳离子肽；（2）研究阳离子肽与多金属氧簇在水溶液中的自组装行为，构筑有序纳米结构；（3）以多金属氧簇为催化中心，阳离子肽组装体为手性环境开发新型手性催化体系；（4）探索组装体形貌及尺寸对阳离子肽抗降解及抗菌效率的影响；（5）实现磁性多金属氧簇在胞内的增强成像。

Co-assembly between cationic peptides and polyanions is an important way to simulate specific biological structures and create novelly functional materials, which has significant potentials in the fields of chemistry, biology and medicine. However, the current problem is that the types of polyanions are limited and the functionality in the assemblies is largely insufficient. We herein try to fabricate ordered supramolecular assemblies by integrating cationic peptides with functional polyoxometalates through ionic self-assembly strategy. It is expected that the chirality and/or the self-assembly features of cationic peptides can be perfectly combined with the catalysis and photo properties of polyoxometalates. Additionally, we will focus on the synergistic bio-activity between peptides and polyoxometalates. This proposal mainly includes four part: (1) the design and synthesis of amphiphilic cationic peptides with unique residues; (2) the aqueous assembly behavior between cationic peptides and polyoxometalates and the fabrication of ordered nanostructures; (3) the development of novelly chiral catalysis by taking advantage of the catalytic property of polyoxometalates and the chiral miro-environment of cationic peptides; (4) the exploration of the relationship between the morphology or size of the ordered assemblies and their bio-activities, involving in the resistance to enzymatic degradation, the antibacterial efficiency; (5) the study on the intracellular magnetic resonance imaging properties of polyoxometalate.