高烯丙基胺是一类非常重要的化合物，发展新的、高效的合成方法有着重要意义。高烯丙基胺一般可以由烯丙基碳负离子对亚胺的亲核加成来制备，其中烯丙基碳负离子大多由烯丙基卤代物与当量的金属试剂反应制得，反应条件要求高，环境压力大。a-胺基碳负离子是一种非常有用的中间体，它与烯丙基化试剂的反应是一种合成高烯丙基胺化合物的新策略。但a-胺基碳负离子不易得到，运用Aminative Umpolung的策略,由醛生成α-胺基负离子，再与易得的烯丙基化试剂反应，可以高效地合成高烯丙基胺。该过程同时构建了新的C-C和C-N键，并且原料简单易得,反应收率高，区域选择性好，条件温和，具有很好的合成和实用价值；另外，该反应底物的电子极性与传统合成方法的相反，具有不同的底物适用范围和官能团兼容性，有利于进一步扩展高烯丙基胺的合成方法及其在有机合成中的应用。该课题的发展对于有机合成、医药、精细化工等领域都有重要意义。

Homoallylic amines are a class of important molecules which have served as valuable precursors for the synthesis of a variety of heterocycles, natural products, and pharmaceutical compounds. The synthesis of homoallylic amines has attracted much attention.The traditional synthetic routes to homoallylic amines often relied on the addition of nucleophilic allylic organometallics to imines. Conversely, the addition of α-amino anions to electrophilic allylic cations afforded a complementary and attractive approach for the synthesis of homoallylic amines. However, it is not easy to obtain the α-amino anion equivalents directly from amines.In this context, decarboxylation of amino acid derivatives provides a mild way for the generation of the nucleophilic α-amino species.Given the ready availability of aldehyde feedstocks, generation of nucleophilic α-amino anions directly from aldehydes would be highly attractive. In this project, we found that that metal carboxylate salt of 2,2-diphenylglicine imine, facilely obtained from aldehyde by condensation with 2,2-diphenylglicine, underwent decarboxylation to generate α-imino anions, which displayed high reactivity and excellent enantioselectivity in Pd-catalyzed allylation to give a variety of homoallylic amines in good yields. The process can be extended to the synthesis of chiral homoallylic amines by using chiral ligands. The reaction is featured with several obvious advantages including ready availability of starting materials, very mild reaction conditions, simple manipulation, high reaction efficiency, and excellent selectivities. We believe that the detailed research on this project would be of interest and importance to organic synthesis and chemical industry.