慢加急性肝衰竭（ACLF）起病急，病程进展快，病死率高，严重威胁慢性肝病患者的生命。而在我国，ACLF发病的主要诱因是乙肝病毒再活化，因此阐明HBV再活化导致ACLF肝损伤的相关机制，对于提高ACLF的诊治水平，改善患者生存状况具有重要意义。本研究以ThGM细胞及其效应因子GM-CSF为切入点，鉴定不同疾病状态下ThGM细胞的变化特点，探讨其与ACLF疾病进展的关系，同时分析相关效应机制，期望为完善疾病的早期预警提供可靠数据，同时为ACLF的临床治疗提供可能的干预靶点。

Acute-on-chronic liver failure is characterized by acute onset, rapid progression and high mortality. It is a serious threat to the lives of patients with chronic liver disease. In China, the main cause of the pathogenesis of ACLF is the hepatitis B virus reactivation. So elucidation the mechanisms of HBV reactivation associated ACLF is important for improving the diagnosis and treatment of ACLF, and has an important significance to improve the patients survival. In this study, ThGM cells and its effect factor GM-CSF as the breakthrough point to identify the phenotype of ThGM cells, and to explore the relationship with progression of ACLF. Furthermore, to analyze the associated mechanisms, expected to provide reliable data for improving the early-warning of disease, and provide possible intervention target for clinical treatment for ACLF.