血管内介入弹簧圈栓塞治疗是一种安全、高效且微创的颅内动脉瘤治疗技术，然而栓塞后动脉瘤的远期复发率偏高是当前需要解决的主要问题。颅内动脉瘤栓塞后复发的生物学机制目前尚不清楚。以往研究表明：从骨髓动员，存在于外周血中的内皮祖细胞是血管再生和损伤后内膜修复的源泉细胞。我们的前期研究已证明内皮祖细胞参与了动脉瘤栓塞后瘤颈内皮化的过程，而瘤颈内皮化的不完整是导致动脉瘤栓塞后远期复发的主要原因。近年来研究发现，他汀类药物具有动员和促进内皮祖细胞增殖的作用，这种作用是独立于其降脂作用之外，通过PI3K/AKT等多种通路和释放VEGF等细胞因子，进行调节。在本研究中，我们将利用瑞舒伐他汀动员内皮祖细胞，观察其促进动脉瘤颈内皮化进程的作用，从而探索药物治疗降低动脉瘤栓塞后远期复发率的可能性；并进一步通过体内、外研究阐明瑞舒伐他汀的作用机制。

Coiling is a safe, efficient and minimally invasive technique in intracranial aneurysm therapy. However, relatively high recurrent rate of coiled aneurysms during long time follow-up remains a problem. The biological mechanism of recurrence of coiled aneurysm is underdetermined. The endothelial progenitor cell (EPC), characterized by hematopoietic stem cell and endothelial cell marker, is a sort of monocyte with potency of differentiation into endothelial cell (EC). EPC shows significant promotion effect via paracrine. EPC plays a significant role in the endothelialization of coiled aneurysmal neck, which was determined in our previous study and considered to be an important step of the endothelialization of coiled aneurysmal neck. Recent studies have illuminated that statins played a cardinal role in promoting proliferation, function and suppressing apoptosis via PI3K/AKT pathway and VEGF releasing, independent of its lipid-lowering effect. In this study, we will explore the effectiveness and detect the mechanism of statin in optimizing the endothelialisation of the aneurysm neck.