肺癌及其骨转移瘤的早期诊断和增强其放射治疗效果是一项难题，我们拟构建两种靶向性、水溶性、生物相容性和放射增敏效果俱佳的纳米放射增敏剂。第一种以聚集诱导发光材料为核心，纳米抗体或亲和小体为靶向分子，此为外部放射源的放射增敏剂；内部放射源的增敏剂以铁卟啉与放射性碘元素为核心，纳米抗体或亲和小体为靶向分子，此为内部放射源的放射增敏剂。此两种放射增敏剂均以PD-L1分子为靶向，以双光子光动力治疗为辅助，实现肺癌及其骨转移瘤的放射增敏效应，并均可呈现肺癌及其骨转移瘤裸鼠模型的靶向近红外光谱成像；第二种放射增敏剂还具有对肺癌及其骨转移瘤通过PET-CT靶向成像进行早期诊断的价值。此两种放射增敏剂均具有微小尺寸和主动靶向性，可进入肺癌及其骨转移瘤深部。本项目可解决肺癌及其骨转移瘤难以早期诊断和放射治疗效果不佳的关键问题，为肺癌及其骨转移瘤的临床早期诊断及提升放射治疗效果提供坚实的实验基础和理论依据。

The early diagnosis of lung cancer and its bone metastases and the enhancement of its radiotherapy effect are a problem. We intend to construct two kind of radiation sensitizers nano-systems with good targeting, excellent water solubility, good biocompatibility and ideal radiosensitization effects. The first one is based on the aggregation-induced luminescent material, the nanobody or affibody is the used as targeting molecule, and this radiosensitizer nano-system apply external radioactive source; the second use the iron porphyrin and the radioactive iodine element as the core, and nanobody or the affibody is used as a targeting molecule as well, this radiation sensitizers nano-system apply internal radioactive source. Both radiosensitizer nanosystems are targeted by PD-L1 molecules, and both are assisted by two-photon photodynamic therapy to achieve radiosensitization effects of lung cancer and bone metastases, and can image lung cancer and bone metastases exhibit targeted near-infrared spectroscopy imaging of the mouse model; the second radiosensitizer also has early diagnostic value for PET-CT targeted imaging of lung cancer and its bone metastases. These two radiosensitizer nano-systems own small size and active targeting ability and are able to enter deep lung cancer and its bone metastases. This project can solve the difficult problem of early diagnosis and poor radiotherapy for lung cancer and its bone metastases. It provides a solid experimental basis and theoretical basis for the early diagnosis and the improvement of radiotherapy of lung cancer and its bone metastases.