基于“神经-内分泌-骨”的轴线调节理论，周围神经损伤后会引起骨代谢的异常，增加骨折的风险。改善失神经后骨质量的问题，要从“神经学”和“力学”两个方面入手。但是对于神经和骨骼的具体关联机制目前不是十分明确，近年研究证实：血管和成骨是骨修复两个重要的过程，负荷诱导的Wnt/β-catenin成骨信号是由NGF-TrkA信号所调节的。因此，我们提出：“夹脊电针结合跑台训练促进坐骨神经损伤大鼠胫骨重建与增加NGF-TrkA与Wnt/β-catenin信号通道的VEGF、NGF、TrkA、PI3K、β-catenin、Osterix的表达有关”之假说。本项目建立大鼠坐骨神经损伤模型，从行为学、形态学、分子生物学等角度，探讨夹脊电针结合跑台训练促进骨质改善的作用机制，为其临床应用提供理论依据。

The injury of peripheral nerve will cause abnormal bone metabolism and increase the risk of fracture ,based on the axis regulation theory of “neuro-endocrine-bone”, To improve the quality of bone after denervation, we should start from two aspects: “neurology” and “mechanics”. However, the specific correlation mechanism between nerve and bone is not very clear at present. The recent studies have confirmed that blood vessels and osteogenesis are two important processes of bone repair, and the load-induced Wnt/β-catenin osteogenesis signal is regulated by the NGF-TrkA signal. Which put forward our hypothesis that treatment of electro-acupuncture at Jiaji acupoints combined with treadmill can promote the tibial reconstruction and increase the expression of VEGF, NGF, TrkA, PI3K, /β-catenin and Osterix in the NGF-TrkA and Wnt /β-catenin signal pathway in rats with sciatic nerve injury. In this study, we established a sciatic nerve injury rat model to explore the mechanism of action to improve the bone quality through the Jiaji-EA technique combined with treadmill training technology from the perspectives of behavior, morphology and molecular biology, so as to provide the theoretical basis for its clinical application.