角膜屈光手术中调整Kappa角的偏移效应，减少术后的高阶像差，已成为共识。但在前期研究中，我们发现适宜角膜屈光手术人群中Kappa角的离散程度较大，Kappa角的补偿值和波前像差的各组成部分与视觉质量之间的对应关系以及与各种个性化切削模式的数字化关系仍有待进一步探索。研究表明，Kappa角补偿的波前引导LASIK的术后视觉质量与术前预测的理论计算结果尚存明显差距。如何根据不同个体的Kappa角及眼光学结构特性做到真正的个性化切削成为角膜屈光领域最热点的话题。本课题拟建立符合人眼Kappa角解剖结构和光学特性的准分子激光角膜切削模型，以及在此基础上，建立个性化的模拟人眼的波前像差光路实验系统。阐明Kappa角动态补偿与成像质量之间的对应关系以及与各种模式的个体化切削之间的数字化对应关系,为设计最优化的符合个体化人眼光学特性的飞秒激光联合准分子激光原位角膜磨镶术提供可靠的理论和实验基础。

It has become the consensus to reduce the postoperative high-order aberration by adjusting the deviation effect of Kappa angle in corneal refractive surgery. But our previous studies found that Kappa Angle showed high degree of dispersion in people suitable for corneal refractive surgery. Our research also showed the digital relationships between kappa Angle compensation and visual quality, various models of personalized cutting, components of wavefront aberration were still unclear. Studies have shown that there is a significant difference between the postoperative visual quality of Kappa angular compensation wave-front guided LASIK and the theoretical calculation results of preoperative prediction. How to achieve the real personalized cutting according to the different individual Kappa Angle and ophthalmological structural characteristics has become the hottest topic in the field of corneal refractive index. This subject is to establish an excimer laser corneal cutting model that conforms to the anatomical structure and optical characteristics of Kappa Angle of human eyes. On this basis, to build a personalized experimental system of wavefront aberration optical path that be able to simulate human eyes. To expound the following: corresponding relation between dynamic Kappa Angle compensation and imaging quality; the digital correspondence between various patterns of the individual cutting. To provide a reliable theoretical and experimental basis for designing Femtosecond laser combined with excimer laser in situ keratoplasty in accordance with individual human eye optical characteristics.