缺血再灌注损伤（ischemia-reperfusion injury，IRI）是肝切除及肝移植术中常发生的病理生理过程。目前临床对其监测手段单一，主要为监测肝功能。CT、MR检查因其仪器无法移动而难以应用于术后重症监护患者，超声检查灵活、方便、可在床边进行的优点使其成为重症监护患者的首选影像学检查方法。病理生理学研究证实：肝脏IRI进程中，同时伴随着肝实质坏死、纤维化形成导致的组织硬度增加及肝内微循环障碍导致的血流灌注改变。因此本研究拟建立新西兰兔阻断入肝血流的肝切模型及肝硬化新西兰兔阻断入肝血流的肝切模型，利用弹性成像及超声造影技术从肝脏质地及血流灌注两方面监测肝脏IRI进程，并与病理、实验室检查、MR检查对比分析，阐明弹性成像及超声造影成像技术评估肝切除过程肝脏IRI的机理，探讨弹性成像联合超声造影成像技术无创性评估肝脏IRI的可行性。并进行临床实验，进一步验证其临床应用价值。

Ischemia-reperfusion injury (IRI) is the most frequent pathophysiologic procedure during liver resection and liver transplantation. Surveillance of liver IRI procedure in clinic is insufficient and mainly for monitoring liver function. CT and MR is hard to be used in postoperative intensive care therapeutic patients due to irremovability and Ultrasound is the preferred imaging method in those patients due to the advantages of flexible, convenient and easy carrying out at the bedside. Study of pathophysiology demonstrate: during the procedure of liver IRI, stiffness of liver parenchyma progress due to hepatocyte nocrosis and fibrosis, and microcirculation obstruction lead to blood flow decrease in liver. Therefore, this study intends to establish the model of New Zealand rabbits with liver resection following blocking blood supply and the model of cirrhosis New Zealand rabbit with liver resection following blocking blood supply, employ Elastography and contrasted enhanced Utrasound (CEUS) to monitor liver IRI from liver stiffness and blood flow and compare with pathology, laboratory examination and MR, clarify the mechanism of Elastography and CEUS in monitoring liver IRI, investigate the feasibility of combining Elastography with CEUS in monitoring liver IRI. This study also intends to carry out clinical trial and further identify the clinical value of combining Elastography with CEUS in monitoring liver IRI.