离子型单一异构体β-环糊精衍生物的合成及在CE手性药物分离中的应用研究

手性药物对映体分离已成为分析化学领域最具挑战性的研究课题之一。环糊精(CD)及其衍生物(CDs)是毛细管电泳法（CE）中使用的优良手性选择剂。同以往使用普通型CDs（混合物）相比，应用单一异构体型CDs（化合物）进行对映体分离不但能保证分析结果的重现性，而且有利于研究CDs与药物主客体之间的作用机制，因此受到化学家们的大力提倡。本项目拟设计合成新的阴阳离子型单一异构体β-CDs，并用于CE手性药物分离研究。考察影响对映体分离的因素，总结分离规律；探讨β-CDs结构与分离效能的关系；用NMR和分子模拟技术研究β-CDs和药物对映体分子之间的相互作用，阐明β-CDs的立体选择性作用机制。为指导CDs类手性选择剂的设计和选择、指导分离实验提供理论和实践的支持。

The enantiomeric separation of chiral drug has become one of the most challenging research topics in the field of analytical chemistry. Cyclodextrins（CDs）and their derivatives (CDs) have been considered as excellent chiral selectors in capillary electrophoresis (CE). Compared with using mixtured CDs, application of the single-isomer CDs for enantiomeric separation can not only guarantee the reproducibility of analytical results but also is conducive to the study of host-guest mechanisms of interactions between CDs and chiral drugs. In this study, synthetizing novel cationic/ anionic single-isomer β-CDs as selectors will be carried out for the purpose of enantioseparation of chiral drugs by CE. And then the influencing factors of enantioseparation will be investigated and the separation rules of single isomerβ-CDs will be summarized. Researches on the relationship between structure and separation performance will also be taken by NMR and molecular modeling. The project will provide theoretical and practical support for guiding the design and choose of CDs as chiral selectors, and directions for separation experiments as well.