全球变暖会极大的影响人类健康尤其是蚊媒传播的疾病。白纹伊蚊是登革热等疾病的传播媒介。气候变化引起蚊虫种群动态，生理行为，物种表现型和基因型，扩散能力发生一系列适应性改变，其机制不明。本项目：⑴我国不同地理区域白纹伊蚊种群的遗传学差异和南方种群入侵北方的分子生物学印记研究,用RAD基因组深度测序寻找Haplotype 和SNP的差异，鉴定我国不同地理白纹伊蚊种群遗传结构。⑵我国南北方地区不同环境条件下的白纹伊蚊对登革病毒感染性差异比较，⑶鉴定我国南北方地区不同环境条件下的白纹伊蚊的RNAi通道特征，⑷研究我国南北方地区不同环境条件下的白纹伊蚊与登革病毒的相互作用，揭示南北方白纹伊蚊对登革病毒易感性差异内在机制。⑸采用贝叶斯时空地理统计学模型，预测我国未来50年在气候变暖的情况下登革热爆发可能波及的新的地理区域以及影响的人口。其目的是解决未来登革热等蚊媒传染病防治领域的相关科学问题，意义重大。

The global warming will greatly influence to human health especially the mosquito borne great. Aedes albopictus is diseases such as dengue fever media. Mosquito population dynamics, physiological behavior ，expression type and genotype , its diffusion capacity of a series of adaptive changes occur , will be caused by climate change , the mechanism is unknown.The research contents of this project:⑴ We used restriction site associate DNA (RAD) sequencing for the discovery of gernome-wide single nucleotide polymorphisms(SNPs) and haplotype. We aimed to characterize the population genetic structure of Aedes albopictus from geographic. The genetic mapping of infected dengue virus mosquitoes will be structured by using SNP and microsatellite SSR molecular markers and QTL analysis, we will search for susceptibility genes and resistance gene of mosoquitoes. We aimed to reveal in the phenotypic characteristics of mosquitoes competent influenced by different geographic populations in China of Aedes albopictus genetic and environmental factors . ⑵The north and south area of our country under different environmental conditions of Aedes albopictus to dengue virus infection difference will be compared .⑶The RNAi channel characteristics under different environmental conditions of Aedes albopictus from northern and southern regions of china will be identify. ⑷The interaction with dengue virus under different environmental conditions of Aedes albopictus in southern North China will be researched. The results may reveal the north and south of Aedes albopictus to dengue virus susceptibility difference mechanism.⑸Using Bayesian spatial-temporal geographical statistical models ,we forecast the next 50 years under climate warming of dengue fever outbreak possible wave and the new regional geography and the effects of the population. The establishment of disease early warning system will provide new strategies and methods for the prevention and control of mosquito and mosquito borne diseases.Its purpose is to solve the future of dengue and other mosquito borne infectious disease prevention and control of related scientific issues, significant.