二氧化碳刺激响应高分子体系的构筑与功能研究

本项目致力于含二氧化碳刺激响应链段的嵌段共聚物、梳形共聚物的可控合成、组装形貌调控与功能调控研究。包括构筑多种二氧化碳响应的聚合物组装体，研究其在二氧化碳氛围内的形貌转变，进行生物模拟，探索仿生组装体形貌转变规律，运用气体可逆调控聚合物形貌；使用二氧化碳气体驱动高分子膜透过率改变，模拟细胞体行为和功能，构筑具有二氧化碳响应的仿生大分子纳米分离器和纳米反应器；构筑具有二氧化碳响应纳米通道的膜材料；构筑通过二氧化碳进行尺寸调控和功能材料释放的水凝胶。 开拓较新的刺激响应调控方式- - 气体调控，阐明胺、脒、胍等二氧化碳刺激响应基元在响应模式、响应程度上的规律，实现刺激响应的敏感性、高效性，解决合成方法简易性、实用性问题。通过气体调控纳米粒子、蛋白、功能分子的分离、释放、参与反应，调控手段简单，控制过程清洁快速。本项目将建立构筑二氧化碳刺激响应聚合物体系的有效方法，具有重要科学意义和宽广应用前景。

This project aims at the study of the controlled synthesis, morphology-tuning and function-tuning of block copolymer and comb copolymer with carbon dioxide stimuli-responsive block by using carbon dioxide. We design and develop biomimetic polymersomes, polymer membrane, and polymer hydrogel,which can reversibly respond to carbon dioxide and nitrogen, and perform a distinctive breathing function. It is expected that the carbon dioxide responsive polymersomes would open a door to mimic the cytomembrane and understand cellular biofunction. By regulating carbon dioxide stimulation time to induce the growth of these polymersomes, polymer membrane, and polymer hydrogel, tunable permeability could be introduced in the membrane. Utilizing such a controlled semi-permeability, we could enable the polymersomes or polymer membrane to realize the hierarchical cargo release and the selective separation of guest molecules according to their size differences. Furthermore, we will use the vesicle or membrane as nanoreactor to divide different enzymatic catalytic reactions in spatial and temporal scale by simply modulating the carbon dioxide treatment levels. The project will develop a new stimuli-responsive mode, that is gas stimuli. We will clarify the regularity of the responsive time and responsive degree of amine, amidine and guanidine on carbon dioxide. We will pay attention to the high sensitivity and high efficiency of response, and the simple and practical synthesis. Through the gas control, the separation, release and reaction of different size nanoparticles, protein, and functional molecules could be realized. The control method is simple, control process is clean and fast. This project will build the effective method for carbon dioxide stimuli-response polymer system.The project has important scientific significance and broad application prospect.