随着创伤急救系统的不断完善和急救技术的不断改进，严重创伤病人因创伤本身即刻致死的死亡率已显著降低，创伤的严重并发症，如脓毒症及其引发的多器官功能障碍，对人类健康造成更大的威胁。BTLA基因与炎症和免疫反应密切相关，我们的前期研究发现，BTLA基因的3’UTR区突变rs1982809在贵州人群中与脓毒症和多器官功能衰竭发病率密切相关，生物信息学分析提示该位点可能是功能性位点。为深入研究其功能意义，本课题拟从rs1982809对BTLA mRNA表达水平/稳定性的影响，或影响BTLA基因与miR-25结合进而改变下游炎性因子的表达水平，从而影响炎症反应平衡，最终改变创伤并发症的发生发展这几个方面着手，系统深入的研究rs1982809影响创伤后并发症发生发展的机制。深入研究rs1982809影响严重创伤并发症发病率的分子机制，有望为脓毒症预警防治提供新的有效生物标志。

With the improvement of traumatic emergency system of the first aid technique, the mortality of patients with severe trauma due to the trauma itself has significantly reduced. Severe trauma complications, such as sepsis and Multiple Organ Dysfunction Syndrome (MODS), cause a greater threat to human health. BTLA gene plays an important role in the immflamation and immune related diseases. Our previous studies have found that a 3’UTR single nucleotide polymorphism (SNP) of BTLA rs1982809 has close relationship with the morbidity of sepsis and MODS. Bioinformatics analysis suggests that this SNP may be a functional loci. In order to further clarify the functional significance of rs1982809, we attempt to reveal the influence of it on the expression level and stability of BTLA mRNA, or the combination of BTLA gene with miR-25, thus affecting the inflammatory balance, and ultimately affect the morbidity of trauma complications. This study was designed to demonstrate the functional significance of BTLA rs1982809 and clarify the mechanism of its impact on the outcome of the severe trauma patients. It will provide a new molecular marker for the early warning of complications of severe trauma patients.