基于杂多价识别的超分子化学传感阵列

阵列传感在判别复杂体系上有着重要的科学意义和实际应用价值，发展新的识别传感策略与材料在构筑新的阵列传感器上尤为重要。杂多价识别融合了杂位点识别与同多价识别的特性，在同一传感单元上构筑不同且多重的识别位点，能够有效提升对复杂体系多种内容物的相互作用强度与识别特异性，对复杂体系的判别具有独特的优势。本项目中我们以有机合成为基础，以杂多价识别为策略，以复杂体系判别为应用出口，设计合成一系列两亲杯芳烃与两亲环糊精衍生物，共组装构建杂多价识别平台，利用杂多价识别位点多样、键合选择性高、传感单元排列组合丰富的特点，发展新的超分子荧光传感阵列体系，实现对酒类、蜂蜜乃至蛋白、细胞等与生产生活和生命健康息息相关的实际复杂体系样品的判别区分，为复杂体系的辨别提供高通量、快速、简单且有效的检测方法，延伸大环化学在质量检测、疾病诊断等领域的应用范围，也为化学传感阵列提供新的构建材料。

Chemical sensor array plays an important role in identifying complex systems. The development of new recognition sensing strategies and materials is particularly important in constructing new sensor arrays. Heteromultivalent recognition combines advantages of heterotopic recognition and homomultivalent recognition, which effectively improves the interactions with multiple contents in complex systems, and has unique advantages in distinguishing complex systems. In this project, we will synthesize a series of amphiphilic calixarene and amphiphilic cyclodextrin derivatives to construct supramolecular fluorescent sensor arrays, and use these arrays for distinguishing wine, honey, even protein and cells, etc. We will provide a high-throughput, fast, simple and effective method for identifying complex systems, extend the application of macrocycles in the fields of quality inspection and disease diagnosis, and also provide new construction materials for chemical sensor arrays.