Manzamine A 是一个具有多环结构的生物碱，同时具有非常广泛的生物活性，包括：细胞毒素作用，抗菌作用，抗疟作用，杀虫作用，抗炎作用和抗HIV病毒的作用，尤其是对老鼠P388 白血病细胞具有极强的细胞毒性作用(IC50=0.07ug/mL)。由于广泛的生物活性和复杂的化学结构，吸引了世界上许多著名合成化学家的关注。目前已经有三个有关全合成的报道，但所报道的合成路线较长且烦琐，总产率低，从而限制了对该分子的成药性研究。本项目拟以全新的合成路线，采用高度汇聚式的合成策略，将高合成难度的Manzamine A的复杂结构通过分割简化成三个简单的合成结构砌块。由此三个砌块合成Manzamine A的方法是一些高效率的成熟可靠的反应。同时，从廉价易得的商业原料开始，使用简单的试剂和常规易操作的反应就可以分别得到数量可观的各个合成中间体砌块。

Manzamine A, a structurally complex alkaloid, is reported to have broad and significant biological activities, including: cytotoxic, antibacterial, antimalarial, insecticidal, anti-inflammatory, anti-HIV, and most notably, the potent cytotoxicity against murine leukemia P388 cell lines (IC50 = 0.07ug/mL). Owing to its broad and potent biological activities and the complex chemical structure, manzamine A has attracted world-wide attention of synthetic chemists. While three total syntheses have been published so far, all of them have suffered from a long reaction sequence and low overall yield. Therefore, it is still in need of more efficient and practically feasible synthetic strategies for the synthesis of manzamine A so that further biological studies can be performed. In this proposal, the authors plan to use a novel and highly convergent synthetic strategy to construct the molecule using highly efficient and reliable chemical reactions from three building blocks, which may be synthesized by using readily available starting materials, cheap regular reagents, and conventional reaction conditions.