基于有机大环的新型超分子催化研究

超分子催化是当前超分子化学和催化研究中的前沿热点领域。本项目将结合超分子过渡金属催化和大环笼状分子模拟酶催化的特点，将底物预组织、手性辅助因子催化等原则引入到新型的有机大环超分子催化体系的设计与合成中。构筑既含有硫脲催化基团、又包含额外键合位点的双功能化有机大环，利用非共价作用引入手性辅助因子，实现对硫脲催化基团手性因素便利的非共价键修饰与筛选，以获得高催化活性与对映选择性，并阐释大环催化体系的主客体作用机制特别是催化过程中手性因素的诱导与转移机制。

Supramolecular catalysis is an emerging and important research topic in supramolecular chemistry and catalysis areas. This project will take advantage of the features of supramolecular transition-metal catalysis and cage-compounds based enzyme-mimics, apply substrate-preorganization, chiral-cofactor concepts into a novel organic macrocycle catalysis system. Accordingly, bifunctional organic macrocycles bearing a thiourea catalytic moiety and an additional recognition site will be constructed. The chiral cofactors will be employed through non-covalent binding to the recognition site, and the caused convenient modulation and screen of the chiral factors for the thiourea catalytic functionality will be explored, aiming for high catalytic activity and enantioselectivity. The host-guest interaction and catalytic mechanism especially the chiral induction and transfer mechanism will be also investigated.