传统中医认为，“内风暗旋”是肿瘤疾病的主要病理特点，机体阴阳气机失调导致内风产生，加速邪实聚集。这与现代药理学研究的肿瘤能量代谢异常的特征十分吻合。“风药抗肿瘤”正逐渐形成一种新的中药抗肿瘤理论。现代药理学已有风药抗肿瘤的研究，但是风药是否通过调节能量代谢发挥抗肿瘤作用仍不明确。申请者前期发现，具有祛风除湿作用的中药淫羊藿中的活性成分Icariside II和割舌树中的活性成分Walsuronoid B 均能够抑制肿瘤细胞mTOR/4E-BP1信号通路并可抑制糖酵解。基于此，研究者发现祛风解表药苍耳子中主要成分苍耳亭（Xanthatin）可以抑制结肠癌细胞增殖并降低细胞内mTOR磷酸化水平。本项目拟在前期研究的基础上，进一步探讨苍耳亭是否通过抑制mTOR/4E-BP1信号通路调控肿瘤能量代谢异常，从而发挥抗肿瘤作用。本项目为中药抗肿瘤开拓新的思路，并且为临床应用中药治疗肿瘤提供理论支持。

Traditional Chinese medicine believes that the “endogenous wind-evil secret whirling” is one of the pathology characteristic of tumor，the Yin Yang Qi disorder lead endogenous wind generation, accelerate the aggregation of pathogenic factor. This is coincided with the characteristics of the energy metabolism dysfunction of the tumor in modern pharmacology. "Anti-tumor of wind drugs" is gradually forming a new anti-tumor theory of traditional Chinese medicine. However, whether the anti-tumor effect of wind drugs through regulating energy metabolism is still unclear. Previous study found that Icariside II and Walsuronoid B, which from herbs of dispelling wind and eliminating dampness，inhibited mTOR/4E-BP1 signaling and reduction of glycolysis. Preliminary studies found Xanthatin, which from Xanthii fructus, inhibited the proliferation of colon cancer and decreased the activity of mTOR. We further investigate weather Xanthatin inhibited tumor energy metabolism through inhibited mTOR/4E-BP1 signaling, thus exert anti-tumor effect. This project enriches the scientific significance of traditional Chinese medicine in the treatment of tumor and provides a theoretical basis for clinical applications.