基于炔丙醇的串联反应研究

炔丙醇是有机合成化学中一类非常有用的化合物。由于其独特的结构以及良好的反应性，炔丙醇一直以来都受到了化学工作者的青睐，被广泛地应用在医药中间体、杂环化合物的设计与合成中。本项目将从炔丙醇出发，系统地研究联烯胺中间体(炔丙醇与胺类化合物反应得到)、联烯酰胺中间体（炔丙醇与酰胺类化合物反应得到）、烯酮亚胺中间体（炔丙醇与叠氮类化合物反应得到）的反应规律性，从而发展一系列以炔丙醇为原料，经由联烯胺、联烯酰胺以及烯酮亚胺中间体的新反应和新合成方法，发展炔丙醇的化学。

Propargyl alcohols are very useful compounds in organic synthesis. Because of its special structure and good reactivity, propargyl alcohols gained a lot of attention of chemists and widely used in the design and synthesis of pharmaceutical intermediates and heterocyclic compounds. This proposal proposed research on the reactivities of allenamines(formation from propargyl alcohols and amines), allenamides(formation from propargyl alcohols and amides) and ketenimines(formation from propargyl alcohols and azides) using propargyl alcohols as starting materials. We would like to develop some new reactions and methodologies of allenamines, allenamides and ketenimines, finally enrich the chemistry of propargyl alcohols.