Mg及其合金可诱导新骨的形成，有望成为一种可降解骨植入材料。针对Mg合金降解速率较快的问题，基于仿生的Mg合金骨植入材料结构功能一体化及其表面涂层生物功能化设计，利用Li,Ca元素对合金表面产物膜独特的致密化作用，从而阻滞析氢的作用,以及涂层中Zn、Ca元素诱导成骨细胞增殖的作用,研究新型Mg-Li-Ca合金及其表面产物膜的物理、化学性质，揭示Mg-Li-Ca合金腐蚀降解机制；研究化学转化工艺参数与Mg-Li-Ca合金组织表面Zn-Ca-P涂层组织、形貌、结合力的关系，揭示离子在Zn-Ca-P涂层中的扩散传输途径和降解规律；考察合金元素Li、Ca和Zn等对骨细胞活性的影响，从而达到调控镁合金降解速率和诱导新骨形成的目的，为发展新型医用Mg合金及涂层体系提供理论依据和设计依据，推进我国医用Mg合金研究的进步，具有深远的科学意义和紧迫性。

Magnesium and its alloys can induce the novel bone formation, and are promising degradable implants. Aiming at slowing the rapid degradation rates of magnesium alloys, the design concepts for the integration of structure and function on magnesium alloys, and for the bio-functionalization of the coatings have been utilized. Lithium and calcium elements have an unique densification of corrosion product layers on Mg alloys, thus impeding the hydrogen evolution; and zinc and calcium elements can enhance osteoblast proliferation in the coatings. The purpose of the project is to investigate the physical and chemical properties of the surface oxide film and corrosion product layers, and to reveal the degradation mechanism of Mg-Li-Ca alloy; to establish the relationship between the chemical conversion parameters and microstructure, morphology and critical adhesion of a Zn-Ca-P coating on the alloy, and to disclose the diffusion process of ions in the coating and its degradation mechanism; and to survey the influence of the elements such as Li, Ca and Zn on osteoblast bioactivity; and consequently to manipulate the degradation rate of the alloy and lead to the formation of new bone, to lay a foundation on the theoretical and design basis for developing new type magnesium alloys and their coatings, also to be helpful for pushing the research progress of the medical magnesium alloys in China. The research has a profoundly scientific meaning and is urgent.