基于9-蒽醚的超分子自组装及其光分解研究

具备光分解特性的超分子组装因其在光降解材料、药物靶向传输以及生物组织工程等领域的广泛应用而备受瞩目。作为光能与化学能间相互转换的关键一环，光分解基团在聚集态下能够高效、可控地进行光分解反应，是其进一步定向调控组装形态的基础。然而，目前常用的光分解基团结构十分有限，因此，发展新的光分解基团进而构筑高效的光分解组装体系十分必要。本项目拟使用9-蒽醚作为一类新型光分解基团。与常规光响应分子不同，蒽醚在单体态活性差，反而在聚集态有较高光分解能力。项目中拟通过研究蒽醚分子结构及组装模式对光分解能力的影响，掌握蒽醚聚集态光活性提升的机理，并得到一系列可高效光分解的超分子组装体系，最终发展出单体态光稳定、聚集态光活性的新型光控组装策略。本项目的研究工作不仅为光控响应基团的设计提供了新的思路，也为不同类型光控基团的正交联用奠定了基础。

Photolyzable assembly has received much attention in the design of degradable materials, targeted delivery vehicles, and tissue engineering systems. As the bridge between light and chemical change, photoreactive group plays an essential role in regulating the morphology transformation of assembly. Owing to the sufficient structural change upon light irradiation, photocleavable groups are widely used to construct photolyzable assemblies. However, only limited classes of photocleavage groups have been extensively studied (i.e., o-nitrobenzyl and coumarin derivatives). Therefore, it is of great importance to develop novel photoreactive groups, which possess efficient photodecomposition as assemblies. 9-Anthryl ether was recently found to exhibit efficient photolysis within amphiphilic nano-aggregates, while it was quite photo-stable as free monomers. This interesting phenomenon endows 9-anthryl ether with potential application in photolyzable matrix. Herein, various supramolecular assemblies based on anthryl ethers with different structures are fabricated, and their photolysis is explored. We expect to shed light on the mechanism of the enhancement of photoactivity within assembly, and propose a novel strategy for light-responsive systems that only aggregated molecules are photoactive. This strategy not only provides a means of designing new light-responsive groups, but also paves the way to developing multi-light-functional assemblies by using combinations of different kinds of photoreactive groups.