慢性硬膜下血肿(CSDH)是老年人常见病，常规需手术治疗，但老年人术后并发症多、复发率高是长期困扰临床的主要问题。本课题组系列研究（Clinics2013）提示：CSDH形成、转归与机体炎症反应和血管新生异常关系密切；我们采用抑炎、促血管修复治疗已获得明确疗效（JNS2015），但作用机制尚不明确，治疗方案有待优化。本研究拟在前期基础上，利用动物模型、体外血管模型、抗体封闭技术及临床验证研究（POC），探索：1.CSDH包膜新生血管渗漏与免疫炎症及血管新生相关因子间关系；2.药物通过CXCR4/SDF-1a系统干预NK和Treg炎症细胞，在调控局部异常炎症反应及促进血肿包膜血管成熟过程中的作用；3.在上述研究的基础上，选择相关药物，优化临床治疗方案，完成POC研究。本研究将探明免疫炎症与血管新生异常在CSDH发生、发展中的作用，优化CSDH临床治疗方案，降低其手术率、减少并发症与术后复发。

Chronic subdural hematoma (CSDH) is a common disease in the elderly. Usually, routine surgical treatment is necessary for CSDH patients. But the elderly with more postoperative complications and high recurrence rate is still a main problem in clinic. This topic research series (Clinics2013) point out: The inflammatory reaction and abnormal angiogenesis are closely related with the formation and prognosis of CSDH; We used anti-inflammation, vascular repair treatment has definite therapeutic effect （JNS2015）,however, the mechanism is not clear, and the therapeutic regimen needs to be optimized. In this paper, on the basis of our previous animal models, vitro vascular model, technology of blocking antibody and clinical curative effect Proof-of-concept study(POC), to explore：1.ralationship among CSDH envelope neovascularization leakage，immune inflammation and angiogenesis related factors; 2. The mechanism of drugs through the CXCR4/SDF-1a system NK and Treg intervention to regulate the inflammatory cells, abnormal local inflammatory reaction and promote hematoma capsular vessels in the vascular mature process; 3. Based on the above research, selected related drugs, optimized therapeutic regimen, completed the POC research. This study will explore the immune inflammation and abnormal angiogenesis in CSDH, optimization of therapeutic regimen of CSDH, reduce the rate of surgery, reduce the recurrence and postoperative complications.