配伍是方剂的核心和灵魂，经方是方剂的精华和典范，是方剂配伍规律研究的切入点。本研究基于我们的前期工作基础，以经方半夏泻心汤为研究对象，在中医方剂配伍理论指导下，按照方证对应和病证结合的原则，从整体动物、器官组织、细胞及分子生物学多层次来评价全方及不同配伍对胃肠动力障碍模型的药理作用。利用LC-MS/MS、LC-LTQ-Orbitrap-MSn等先进的分离分析技术，同步开展病理模型动物的药效成分吸收、分布、排泄、代谢的体内过程。借助复杂系统建模方法，分析化学成分群-体内过程-多重药理效应之间的关系，探寻半夏泻心汤的药效物质基础，诠释其配伍规律的科学内涵和作用机制，为中药复方配伍规律研究提供一种有益的范式。

Compatibility is the core and soul of the traditional Chinese prescription. Classical prescriptions can be taken as the pointcut for compatibility laws study. On the basis of previous study, the classical prescriptions, Banxiaxiexin Decoction, will be studied. Guided by the compatibility theory of the “ prescription and syndrome corresponding principle” and the “disease and syndromes combination principle”, the pharmacological functions to gastrointestinal motility disorder model of Banxiaxiexin Decoction and its various compatibilities will be evaluated from the following four different levels: the whole body, the organ, the cell and the molecular. LC-MS/MS, LC-LTQ-Orbitrap-MSn and other advanced separating and analytical techniques will be taken to analyze the absorption, distribution, metabolism and excretion in vivo course of pathological model of animals. With the help of the complex system modeling methods, the relationship among the chemical constituents, in vivo process of the active ingredients and multiple pharmacological effect will be analyzed. The material basis of Banxiaxiexin Decoction will be explored. The scientific content of prescription compatibility rule and its mechanism will be explained. A useful example for the study of compatible regularity of the TCM will also be provided by interpreting the scientific connotation and mechanism of its compatibility.