猪囊尾蚴病俗称囊虫病，是由猪带绦虫幼虫-囊尾蚴引起的一种呈世界性分布的人兽共患寄生虫病，贵州黔东南、黔南和黔西南为囊虫病高发地区。药物及手术治疗都有其局限性，有保护作用的疫苗将成为控制该病流行的有效工具。尽管前一个已结题国家自然科学基金项目“猪带绦虫重组Bb-TSO45W-4B-TSOL18疫苗构建及其免疫机制研究（81160206）”取得了一些研究成果，但该疫苗诱导的保护力也不那么令人满意。复杂的免疫发病机制将是制约囊虫病疫苗研制的一大瓶颈，结合寄生虫排泄分泌抗原（ESA）研究进展，本项目组提出了猪囊尾蚴ESA可能参与囊虫病免疫发病机制的假说，进一步拟通过建立囊虫病猪动物模型，制备猪囊尾蚴ESA，从DC细胞活化及其抗原提呈、T细胞活化增殖、T细胞极化、Treg细胞及IL-10产生的免疫抑制等方面，探讨猪囊尾蚴ESA在体外诱导的免疫学效应，为揭示囊虫病的免疫发病机制及其免疫预防提供新思路。

Cysticercosis cellulosae is a widespread zoonosis caused by the larval stage of Taenia solium cysticercus. It is distributed in the southeast, south and southwest of Guizhou. Drug or surgery therapy has its limitations. A protective vaccine would be an effective tool for control the prevalence of this disease. Although the former completed National Natural Science Foundation Project-“Construction and immune mechanism of recombinant bifidobacterium(Bb)-TSO45W-4B-TSOL18 vaccine of Taenia solium(NO:81160206)”has made some research results, the protective effect induced by the vaccine was still unsatisfactory.The complex immune pathogenesis will be the main bottleneck restricting the development of cysticercosis vaccine. Combined with the progress of parasite excretion and secretion antigen (ESA), the project team proposed the hypothesis that ESA may be involved in the immune pathogenesis of cysticercosis. Pigs are used to establish the animal model infected with cysticercosis. cysticercus is collected to prepare ESA. According to the following aspects, such as dentridic cell(DC cell) activation and presenting antigen, T cell proliferation and polarization, Treg cells and IL-10 immunosuppression and so on, this project will explore the immunological effect induced by cysticercus ESA in vitro. It will provide a new idea for revealing the immune pathogenesis and immune prevention of cysticercosis.