导管消融隔离左心房治疗持续性房颤的实验研究

房颤是临床最常见的心律失常之一,具有较高的致残和致死率。恢复窦性心律是房颤治疗的理想目标。导管消融治疗持续性房颤常需要心房内广泛的消融和多次手术，但长期疗效并不理想。大多数房颤本质上是一种左心房疾病，电隔离左心房能使右心房和双侧心室恢复窦性心律。本项目拟采用动物犬作为实验对象，根据左右房之间电传导通道的解剖位置，在窦性心律下使用射频导管消融电隔离左心房，建立安全有效的左房隔离方案。并在持续性房颤实验犬的模型上隔离左心房，观察左房隔离后左、右心房和心室的节律，随访观察左房隔离对于持续性房颤的长期疗效和安全性。研究结果将为导管消融隔离左房治疗持续性房颤的临床应用奠定基础。

Atrial fibrillation (AF) is the most common arrhythmia encountered by cardiologists and is a major cause of morbidity and mortality. It is an ideal treatment to restore sinus rhythm in AF patients. The long-term outcomes of catheter ablation in persistent AF patients are far from optimal, require the creation of extensive atrial lesions and repeated procedures. AF is essentially a kind of left atrial disease in most cases. Electrical isolation of the left atrium could make the right atrium and both ventricles restored to sinus rhythm. The purposes of this study are to establish a catheter-based interventional technique for left atrial isolation and to investigate the outcome of left atrial isolation for persistent AF. The left atrial isolation would be performed by radiofrequency catheter ablation on the anatomical basis of the interatrial connections. The long.term efficacy and safety of the catheter-based left atrial isolation would be evaluated in a pacing-induced persistent AF canine model. This study may lay a foundation for clinical application of the catheter-based left atrial isolation in patients with persistent AF.