我们前期研究“疏泄”与“润泽”功能和状态是皮毛“微环境”主要特征，也是“皮毛卫外功能”的具体体现，与表皮通透屏障功能有趋同性。其功能障碍在皮肤病病机方面具有普遍性和特征性。“肺-皮毛”功能轴对皮毛“微环境”的调节起到关键作用，“肺-皮毛”功能轴紊乱或是皮毛“微环境”障碍的主要原因。本项目根据前期皮毛“微环境”表征研究积累，通过建立“肺气虚证皮炎-湿疹样病变豚鼠模型”，①研究“肺-皮毛”功能轴失调模型“表皮通透屏障”组织病理改变，水分含量与流失及其中间丝聚合蛋白和肺、皮肤组织水通道蛋白3的表达；②通过经典方剂玉屏风散与消风散，当归饮子合方实验，揭示益肺固表，辛散透表，养血润燥法及其配伍用药对“表皮通透屏障功能”的调控路径和靶点，验证“肺－皮毛”功能轴概念的客观性和经典方药对“肺－皮毛”功能轴障碍的修复作用，为中医治疗皮肤病的关键环节提供研究基础。

Our previous research on "dissipation" and "moisture" function and the main feature of skin "microenvironment", and it is also a concrete manifestation of "skin and outer function", and it has similarity with epidermal permeability barrier function.Its dysfunction is universal and characteristic in terms of dermatological pathogenesis.The “lung-skin” functional axis plays a key role in the regulation of the “microenvironment” of the fur, the main cause of the “lung-skin” functional axis disorder or the “microenvironment” of the fur.This project is based on the preliminary research on the “microenvironment” of skin, and through the establishment of “guinea pig model of spleen-derived dermatitis-eczema-like lesions”, and the pathological changes of the “epithelial permeability barrier” of the “lung-skin” functional axis imbalance model, water Content and loss, sebum content, skin elasticity and its expression of intermediate silk polymer protein and aquaporin 3; secondly through the classic prescription Yupingfeng San and Xiaofeng San, Danggui Yinzi combined experiment, revealing Yifei solid table, Xin Dispersion of the table, nourishing and moistening dryness method and its compatibility drugs on the regulation path and target of "epidermal permeability barrier function", verifying the objectivity of the "lung-skin" functional axis concept and the classic lung medicine "lung-skin" function The repairing effect of shaft obstacles provides a research basis for the key links of Chinese medicine treatment of dermatological diseases.